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Development of proteomic methods for studying cerebrospinal fluid proteins involved in Alzheimer´s disease
(2003)
Alzheimer's disease (AD) is the most common cause of dementia in western countries. The main neuropathological findings in the AD brain are senile plaques, neurofibrillary tangles and degeneration of neurons and synapses. ...
Cerebrospinal fluid biomarkers and cognition in older adults
(2021-04-21)
Alzheimer’s disease (AD) is the most common type of dementia. The cause of the disease is unknown, but a substantial amount of evidence suggest that the disease is started by an imbalance in the production and clearance ...
Varicella-zoster virus infections of the central nervous system
(2013-05-24)
Both varicella (chickenpox), and the reactivated form of herpes zoster (shingles), may cause neurological complications with various central nervous system (CNS) manifestations. Following introduction of PCR as a diagnostic ...
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
(2011-05-27)
Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common ...
Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy
(2021-05-25)
Abstract
Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal ...
CSF biomarkers in idiopathic normal pressure hydrocephalus- Diagnostics and pathophysiology
(2019-05-23)
Idiopathic normal pressure hydrocephalus (iNPH) is a disease of the elderly with enlarged ventricles despite a normal CSF pressure. Clinically, iNPH presents with gait- and balance disturbances, cognitive decline and ...