Dietary patterns linked to symptoms in patients with a disorder of gut-brain interaction
Abstract
Disorders of gut-brain interaction (DGBI) encompass a range of medical conditions characterized by gastrointestinal (GI) symptoms, in the absence of alarm features or organic diseases that explain the symptoms, after a minimal relevant clinical evaluation. With a global prevalence of approximately 40%, DGBI exert a considerable impact on both patients and society as a whole.
The multifactorial pathophysiology of DGBI is only partly understood. During the last decade, research has started focusing on gut luminal factors, including food as pathophysiological factors, as many patients with a DGBI report food intake to be related to symptoms. A few underlying mechanisms for these food-related symptoms have been proposed, including altered nutrient sensing and tasting, physical considerations after food intake, malabsorption, local allergy-like reactions to food, and the interaction between food and microbiota. Nevertheless, how food intake and specific dietary habits may generate GI symptoms currently remains incompletely elucidated.
This thesis examines various aspects of food-related symptoms in patients with a DGBI, all aiming to contribute to the overall understanding of the underlying mechanisms of food-related symptoms and optimizing the diagnosis and management of patients with a DGBI.
Parts of work
1) Colomier E, Melchior C, Algera JP, Hreinsson JP, Störsrud S, Törnblom H, Van Oudenhove L, Palsson OS, Bangdiwala SI, Sperber AD, Tack J, Simrén M. (2022). Global prevalence and burden of meal-related abdominal pain. BMC Med. Feb 17;20(1):71. https://doi.org/10.1186/s12916-022-02259-7 2) Colomier E, Van Oudenhove L, Tack J, Böhn L, Bennet S, Nybacka S, Störsrud S, Öhman L, Törnblom H, Simrén M. (2022). Predictors of symptom-specific treatment response to dietary interventions in irritable bowel syndrome. Nutrients. Jan 17;14(2):397. https://doi.org/10.3390/nu14020397 3) Colomier E, Halminen J, Björck M, Höskuldsdóttir G, Mossberg K, Engström M, Eliasson B, Wallenius V, Fändriks L, Tack J, Törnblom H, Simrén M. Prevalence and factors associated with disorders of gut-brain interaction in obesity before and after treatment. Submitted. 4) Colomier E, Nybacka S, Hreinsson JP, Störsrud S, Tack J, Törnblom H, Simrén M. Habitual dietary intake and diet quality of patients with irritable bowel syndrome vs. the general population. Submitted. 5) Colomier E, Jones MP, Holvoet L, Carbone F, Bai T, Liu J, Melchior C, Gourcerol G, Chuah KH, Hui KX, Mahadeva S, Siah KTH, Lipták P, Banovcin P, Holtmann G, Koloski N, Carabotti M, Annibale B, Suzuki H, Sano M, Ueda T, Hashemi P, Shahoon H, Adibi P, Simrén M, Gwee KA, Tack J. Symptom patterns outside the Rome IV consensus in both Eastern and Western patients with a disorder of gut-brain interaction. Submitted.
Degree
Doctor of Philosophy (Medicine)
University
University of Gothenburg. Sahlgrenska Academy
Institution
Institute of Medicine. Department of Molecular and Clinical Medicine
Disputation
Torsdagen den 7 september 2023, kl. 17.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Date of defence
2023-09-07
esther.colomier@gu.se
Date
2023-08-18Author
Colomier, Esther
Keywords
Disorders of gut-brain interaction
Irritable bowel syndrome
Diet
Publication type
Doctoral thesis
Language
eng