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Nutritional metabolomics: The search for dietary exposure variables
(2018-10-19)
To establish associations and causation between diet and health, objective and reliable methods are needed to measure dietary exposure. Metabolomics provide an unbiased tool for exploring the modulation of the human ...
Health hazards and cancer in relation to occupational exposures among Swedish seafarers
(2018-11-19)
This thesis explores health hazards for seafarers in the Swedish merchant fleet, and occupational risks for lung cancer, mesothelioma and hematologic malignancy (HM). A special focus has been exposure to benzene and biomarker ...
Hearing-related symptoms among women - Occurrence and risk in relation to occupational noise and stressful working conditions
(2018-05-24)
A considerable amount of research has been devoted to the risk of noise-induced hearing loss among industry workers – the majority of whom are men. Much less research has been done in female-dominated human service ...
Androgen receptor signaling mechanisms in bone
(2018-12-13)
Osteoporosis is a common age-related disease that increases the risk of fractures. Androgens are crucial for bone health in males. Although a substantial part of the effects of androgens on the skeleton is mediated via ...
Host-Virus Interactions in Asthma and COPD
(2018-10-26)
Asthma and chronic obstructive pulmonary disease (COPD) are associated with periods of worsened symptoms, known as exacerbations. Severe exac-erbations can result in hospitalisation, irreversible decline of the disease and ...
Women's and Men's Health care utilisation from a cost perspective
(2018-10-23)
The aim of this thesis was to explore sex differences in health care utilisation and costs (i) in a region in Sweden, (ii) in treatment of dialysis patients across the region, and (iii) in the treatment of specified ...
Epidemiological aspects of cardiovascular morbidity and mortality among individuals with diabetes: the relative importance of cardiovascular risk factors
(2018-09-21)
Background: Long-term trends of cardiovascular complications and death among patients with diabetes have not been studied extensively. In addition, we aimed to examine the effect of multifactorial risk factor control, as ...
Defining the importance of protein geranylgeranylation in innate immunity
(2018-11-19)
RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed ...
Platelet activation and aggregation: Clinical and experimental studies
(2018-11-21)
Background: Dual antiplatelet therapy with acetylsalicylic acid (ASA) and the adenosine diphosphate (ADP)-receptor antagonist ticagrelor increases the risk of bleeding complications during cardiac surgery. The overall aim ...
STK25 as a regulator of lipid accumulation
(2018-08-24)
Type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH), a progressive form of nonalcoholic fatty liver disease (NAFLD), have become widespread metabolic disorders that have reached epidemic proportions. ...