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Cadmium, kidney and bone
(2015-11-11)
Toxic heavy metals, such as cadmium, mercury and lead, occur in the environment both naturally and as contaminants due to agricultural and industrial activities. The aims of this thesis were to examine the levels of these ...
Podocyte Melanocortin 1 Receptor Mediated Signaling
(2015-09-10)
Treatment of patients with nephrotic syndrome (NS) is currently unspecific and directed at ameliorating the symptoms rather than eliminating the cause. NS is actually a multitude of glomerular diseases characterized by ...
Obstructive Sleep Apnea in Cardiovascular Disease - Mechanisms and Impact of Treatment
(2015-10-29)
ABSTRACT
Background: Scientific understanding of obstructive sleep apnea (OSA) has increased
exponentially during recent decades, suggesting a link between OSA and cardiovascular disease. Few randomized controlled trials ...
Integrative network modeling of large multidimensional cancer datasets
(2015-10-07)
Our ability to conduct detailed molecular investigations on tissue samples have, during the past decade, enabled the formation of databases containing measurements from thousands of cancer tumors. To harness the potential ...
Evaluation of regression methods for log-normal data - linear models for environmental exposure and biomarker outcomes
(2015-03-03)
The identification and quantification of associations between variables is often of interest in occupational and environmental research, and regression analysis is commonly used to assess these associations. While exposures ...
Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery
(2015-05-06)
Abstract
Excessive bleeding after cardiac surgery is a serious complication that is associated with increased morbidity and mortality. The bleeding is multifactorial and influenced by both surgical factors and impaired ...
Challenges in prevention and timely care of uterine prolapse in Nepal
(2015-12-09)
Background: Uterine prolapse is a common reproductive health problem in low-income countries like Nepal. Physical symptoms of this condition influence women’s quality of life. Current data insufficiently determine women’s ...
Bone density, bone geometry and bone development in young men - the importance of pubertal timing and fracture history
(2015-03-30)
Background and objective: Peak bone mass, the maximal bone mass attained in young adulthood, is an important factor of the lifetime risk of developing osteoporosis. The aim of this thesis was to study the development of ...
Studies on microcirculation in insulin resistance
(2015-11-26)
The overall aim of this thesis was to investigate the microcirculation in insulin resistance, with focus on the expression of endothelin-1, through a translational approach.
Specific aims: 1) Investigate if circulating ...
Obesity - surgical treatment and molecular mechanisms
(2015-11-11)
Obesity is a condition of high prevalence and is associated with increased morbidity and mortality. Bariatric surgery is an effective treatment of obesity and reduces the risk for morbidity and mortality, but little is ...