The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase ...

Rheumatoid arthritis (RA) is a common systemic autoimmune disorder and a debilitating disease affecting 1% of the world population. The etiology of RA is an unresolved issue. Environmental factors such as alcohol intake ...

Rheumatoid arthritis (RA) is a systemic autoimmune joint disease, in which chronic inflammation and hyperplastic synovial tissue mediates destruction of cartilage and bone. Survivin is known as an intracellular inhibitor ...

In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. Blood samples from ...

Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder that primarily affects flexible joints resulting in severe joint destruction and disability if left untreated. Today, advances in treatment ...

Resistin is a protein with proinflammatory properties in man and a regulator of glucose metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent cytokine cascade; however, its full role in ...

Rheumatoid arthritis (RA) is an autoimmune chronic disease that results in damage to tissues throughout the body due to the inability of the immune system in these patients to discriminate between self-tissues and foreign ...

The overall aim of this thesis was to increase the knowledge of molecular mechanisms shaping the pathogenic phenotype of activated fibroblast-like synoviocytes (FLS), which are drivers of chronic inflammation and destruction ...

Abstract: Neutrophils are phagocytes of the innate immune system with prominent roles in host defense and are also believed to be important in autoimmune diseases such as rheumatoid arthritis (RA) by accumulating in inflamed ...

Fms-like tyrosine kinase 3 (Flt3) is a receptor on common stem cell progenitors and has a crucial role in hematopoesis, regulating cell proliferation and differentiation in man and mice. The growth factor Flt3 is activated ...