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Role of environmental toxins in chronic experimental arthrithis - in search for anti-inflammatory pathways of ethanol and nicotine
(2010-11-22)
Rheumatoid arthritis (RA) is a common systemic autoimmune disorder and a debilitating disease
affecting 1% of the world population. The etiology of RA is an unresolved issue. Environmental factors
such as alcohol intake ...
Linking fms-like tyrosine kinase 3 and urokinase signalling to survivin expression in experimental arthritis
(2014-03-07)
Rheumatoid arthritis (RA) is a systemic autoimmune joint disease, in which chronic inflammation and hyperplastic synovial tissue mediates destruction of cartilage and bone. Survivin is known as an intracellular inhibitor ...
Tyrosine kinase Flt3/Flt3-ligand signaling in the modulation of immune responses in experimental arthritis
(2014-01-13)
Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder that
primarily affects flexible joints resulting in severe joint destruction and disability if left untreated.
Today, advances in treatment ...
Resistin is a modulator of inflammation and autoimmunity
(2009-11-18)
Resistin is a protein with proinflammatory properties in man and a regulator of glucose
metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent
cytokine cascade; however, its full role in ...
Smoking and T cell co-stimulation in rheumatoid arthritis
(2019-04-18)
In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1.
Blood samples from ...
The Role Of Serum Amyloid A In Inflammatory Disease - Proinflammatory Mediator Or Inert Biomarker?
(2010-03-31)
Abstract: Neutrophils are phagocytes of the innate immune system with prominent roles in host defense and are also believed to be important in autoimmune diseases such as rheumatoid arthritis (RA) by accumulating in inflamed ...
Self-tolerance in collagen induced arthritis
(2013-04-29)
Rheumatoid arthritis (RA) is an autoimmune chronic disease that results in
damage to tissues throughout the body due to the inability of the immune system
in these patients to discriminate between self-tissues and foreign ...
Estrogen and raloxifene in experimental arthritis and osteoporosis
(2008-02-14)
ABSTRACT
In postmenopausal rheumatoid arthritis (RA), both the estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. This leads to an increased risk of fracture, with ...
Differentiation factor Fms-like tyrosine kinase 3 ligand is a modulator of cell responses in autoimmune diseases
(2012-01-23)
Fms-like tyrosine kinase 3 (Flt3) is a receptor on common stem cell progenitors and has a crucial role in hematopoesis, regulating cell proliferation and differentiation in man and mice. The growth factor Flt3 is activated ...
Fatigue in persons with rheumatoid arthritis: A person-centred physical therapy approach
(2015-08-21)
Fatigue is a prominent symptom in persons with rheumatoid arthritis (RA) with great impact on daily life. Despite the improvement in pharmacological treatment of RA over the last decades, a large number of persons with RA ...