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Microarray analysis of gene expression in human adipocytes and adipose tissue
(2008-02-21)
Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine ...
Diabetes and obesity in primary health care - a condition beyond physiological factors
(2011-11-18)
Aims: The objectives of this thesis are to illustrate how obese and normal-weight individuals with type 2 diabetes (T2DM) experience their health status and health care interactions and to highlight the diabetes team ...
Molecular mechanisms in obesity-associated metabolic disease
(2007-07-12)
Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. This thesis ...
Adipose tissue-derived serum amyloid A and adipose tissue macrophages in metabolic disease
(2013-11-29)
Obesity is associated with a low-grade chronic inflammation with increased levels of proinflammatory markers in the circulation and local inflammation in the adipose tissue. In this thesis, two aspects of obesity-related ...
Cardiovascular and metabolic control in obese children and adolescents
(2008-05-23)
Childhood obesity is an emerging risk factor for disease and mortality worldwide. The cardiovascular consequences and prevention thereof need to be further investigated. Exercise and weight loss are well examined and ...
Body weight, body size and early cardiovascular disease. Epidemiological studies using Swedish registries
(2021-05-04)
Background: Obesity is a known risk factor for cardiovascular morbidity and mortality, as well as for atrial fibrillation and heart failure. While overweight and obesity have become increasingly more common in Sweden and ...
Barriers and Facilitators of Health Promotion and Obesity Prevention in Early Childhood: A Focus on Parents Results from the IDEFICS Study
(2014-02-10)
Background: Childhood obesity has increased dramatically during the past thirty years. Parents are key persons in their children’s lives and their efforts to create healthy lifestyles are very important. However, social ...
Effects of gastric bypass surgery in patients with obesity and type 2 diabetes
(2019-05-17)
Background: The effects of Roux-en-Y gastric bypass (GBP) have not been adequately explored in patients with concurrent obesity and type 2 diabetes mellitus (T2DM) to the same extent as has occurred for individuals with ...
Carbonic anhydrase activity in sleep apnea - a potential therapeutic mechanism for intervention
(2016-11-30)
There is no pharmacological treatment for obstructive sleep apnea (OSA) in clinical practice. The overall aim of this thesis was to investigate the effect of carbonic anhydrase (CA) enzyme activity on sleep apnea severity ...
Heart Failure and Aortic Stenosis - Factors Influencing Prognosis and Development
(2021-04-27)
Background: An ageing population increases the prevalence of heart failure (HF) and aortic stenosis (AS). Several studies have investigated prognosis and predictors of HF with preserved ejection fraction (HFpEF) compared ...