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From Proteomic Analysis to Biomarker Application - Studies of Carbonyl Reductase in Fish


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Title: From Proteomic Analysis to Biomarker Application - Studies of Carbonyl Reductase in Fish
Authors: Albertsson, Eva
E-mail: eva.albertsson@zool.gu.se
Issue Date: 22-Sep-2011
University: University of Gothenburg. Faculty of Science
Institution: Department of Zoology ; Zoologiska institutionen
Parts of work: Paper I: Proteomic analyses indicate induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent. Albertsson, E., Kling, P., Gunnarsson, L., Larsson, D.G.J., Förlin, L., 2007. Ecotoxicology and Environmental safety 68, 33-39.
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Paper II: Induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works—Possible roles of aryl hydrocarbon receptor agonists and oxidative stress. Albertsson, E., Larsson, D.G.J., Förlin, L. Aquatic Toxicology 97, 243-249.
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Paper III: Carbonyl reductase mRNA expression and activities in eelpout and rainbow trout treated with paraquat and β-naphthoflavone. Albertsson, E., Rad, A., Sturve, J., Larsson, D.G.J., Förlin, L. Manuscript

Paper IV: Biomarker responses in eelpout from different coastal sites in Sweden, Denmark and Germany. Albertsson, E., Gercken, J., Strand, J., Asker, N., Bergek, S., Holmqvist, I., Kammann, U., Parkkonen, J., Förlin, L. Manuscript
Date of Defence: 2011-10-14
Disputation: Fredagen den 14 oktober 2011, kl 10.00, föreläsningssalen, Zoologiska institutionen, Medicinaregatan 18, Göteborg
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Fish, Proteomics, Biomarker, Carbonyl Reductase, AhR agonists, Oxidative stress, Biomonitoring
Abstract: Many anthropogenic substances are present in the aquatic environment, but there is limited information on how this combination of chemicals affects exposed wildlife. To assess the impact of chemicals, a biomarker approach is frequently applied in environmental biomonitoring programmes. In this thesis, proteomic analysis was used as a hypothesis generator for biomarker development in fish. Two-dimensional gel electrophoresis was performed on a liver fraction from rainbow trout (Oncorhynchus m... more
ISBN: 978-91-628-8348-5
URI: http://hdl.handle.net/2077/26664
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Zoologiska institutionen
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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