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On the role of genetic variation and epigenetics in hemostatic gene regulation
(2020-01-17)
Many genetic variants have been identified to associate with circulating levels of hemostatic proteins and with thrombotic or hemorrhagic disorders. However, the underlying molecular mechanisms remain largely unknown. ...
FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects
(2021-11-23)
The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, ...
Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
(2020-10-07)
One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis ...
Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials
(2020-01-30)
Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the ...