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HIV Persistence and Viral Reservoirs
(2010-05-28)
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting ...
Cerebrospinal fluid biomarkers and cognition in older adults
(2021-04-21)
Alzheimer’s disease (AD) is the most common type of dementia. The cause of the disease is unknown, but a substantial amount of evidence suggest that the disease is started by an imbalance in the production and clearance ...
CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions
(2011-11-18)
Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and ...
On community acquired infections requiring intensive care
(2015-01-07)
Acute bacterial meningitis (ABM), influenza, and necrotizing soft-tissue infections
(NSTIs) are diseases that in a short period of time can progress to become life
threatening. Individuals with severe forms of these ...
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)
Abstract
Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and ...
Varicella-zoster virus infections of the central nervous system
(2013-05-24)
Both varicella (chickenpox), and the reactivated form of herpes zoster (shingles), may cause neurological complications with various central nervous system (CNS) manifestations. Following introduction of PCR as a diagnostic ...
Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
(2008-04-04)
ABSTRACT
There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact ...
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
(2011-05-27)
Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common ...
On cerebrospinal fluid biomarkers of HIV-1 infection
(2015-11-26)
HIV invades the central nervous system (CNS) shortly after transmission and is present throughout the course of infection, causing immune activation and neuroinflammation. If left untreated, more than 20% of patients with ...
The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance
(2016-05-31)
Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration ...