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Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease


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Title: Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease
Authors: Olsson, Annika 1973-
Issue Date: 2004
University: Göteborgs universitet/University of Gothenburg
Institution: Institute of Clinical Neuroscience
Institutionen för klinisk neurovetenskap
Date of Defence: 2004-04-23
Disputation: Psykiatriklinikens aula (V-aula), Sahlgrenska Universitetssjukhuset/Mölndal, kl. 13.00
Publication type: Doctoral thesis
Keywords: Alzheimer s disease
amyloid precursor protein
ß-amyloid
biomarker
cerebrospinal fluid
enzyme-linked immunosorbent assay
plasma
Abstract: Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). The subsequential cleavages by beta- and gamma-secretase of APP generate Aß and, simultaneously, soluble ß-APP (ß-sAPP). In contrast, alpha-secretase cleavage precludes Aß formation and generates soluble alpha-APP (alpha-sAPP). Abnormal ... more
ISBN: 91-628-6028-3
URI: http://hdl.handle.net/2077/16160
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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