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Effects of GH and liver-derived IGF-I on growth and metabolism


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Title: Effects of GH and liver-derived IGF-I on growth and metabolism
Authors: Sjögren, Klara 1970-
Issue Date: 2001
University: Göteborgs universitet/University of Gothenburg
Institution: Department of Medicine
Avdelningen för internmedicin
Date of Defence: 2001-03-30
Disputation: Föreläsningssal Ivan Ivarsson (A1034), Medicinaregatan 3A, kl. 13.00
Publication type: Doctoral thesis
Keywords: GH
IGF-I
Insulin
GHRH
Somatostatin
GHS
Body growth
Body composition
Liver
Bone mineral content
Bone mineral density.
Abstract: Growth hormone (GH) exerts major effects on body growth and metabolism. Insulin-like growth factor (IGF) is expressed in response to GH and is known to mediate many of the effects of GH. The largest expression of IGF is found in the liver although it is expressed in virtually every tissue of the body. The aim of this thesis was to investigate the effects of GH and liver-derived IGF-I on growth and metabolism, especially the relative importance of liver-derived IGF-I versus IGF-I expressed locall... more
ISBN: 91-628-4712-0
URI: http://hdl.handle.net/2077/15224
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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