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Mechanisms behind anorexia in experimental cancer
(2004)
Cancer anorexia-cachexia syndrome (CACS) is observed in 80% of patients with advanced cancer and is one of the most frequent causes of death in cancer. CACS is multifactorial in origin and involves interactions of cytokines, ...
The inflammatory and immunogenic properties of the receptor for advanced glycation end products and its ligand, high mobility group box chromosomal protein 1
(2005)
Rheumatoid arthritis (RA) is a chronic systemic inflammatory joint disease, the pathogenesis of which is complex, involving a wide range of molecules. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear ...
On the initial inflammatory response to variations in biomaterial surface chemistry
(2004)
Aims. The aim of the present thesis was, firstly, to develop in vivo and ex vivo models for analysis of peri-implant exudate and implant adherent cells and, secondly, to characterize the early inflammatory response to ...
Modulation of cytokine production by mononuclear cells in allergic inflammation. The effects of allergen exposure and anti-inflammatory agents
(2003)
In pollen-sensitized subjects, seasonal allergen exposure results in clinical allergic disease, which in affected tissues displays a morphological picture typical of chronic inflammation. The cellular responses to allergens ...
Systemic inflammatory activation during cardiac Surgery. Influence of cardiopulmonary bypass management and patient factors
(2005)
Cardiac surgery with cardiopulmonary bypass is accompanied by a prominent systemic inflammatory and hemostatic activation, which may contribute to postoperative complications. Aims: To investigate if selection of cardiopulmonary ...
Modulation of inflammation by immunostimulatory DNA
(2004)
The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester ...
Liver transplantation in man. Gastrointestinal perfusion and inflammatory response
(2000)
Patients undergoing liver transplantation develop a systemic inflammatory response which eventually continues with development of a multiple organ dysfunction syndrome (MODS). Gastro-intestinal hypoxia or bacterial ...
Macrophage-material surface interactions
(2000)
Material surface-stimulated activation of the macrophage and the release of mediators has been suggested to be an important factor for inflammation and tissue regeneration around biomedical implants. Macrophage interactions ...