Browsing by Subject "p53"
Now showing items 1-9 of 9
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Hormonal regulation of growth in human endometrial adenocarcinomas. Role of the p53 gene
(1997)Oestrogen is known to have mitogenic effects on human endometrial carcinomas resulting in an increase in tumour volume. In some cases an inhibition of growth has been observed but the mechanism behind this response is not ... -
Long-term survival and prognostic factors in endometrial cancer - a populationbased cohort study
(2019-03-14)Aims: The over-all aims of this thesis were to evaluate the associations between prognostic factors and excess mortality rate, between socioeconomic and immigrant status and incidence rate, in endometrioid (EEC) and ... -
Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ... -
Prognostic and predictive factors in laryngeal cancer treated with radiotherapy
(2006)Radiotherapy (RT) and surgery are the only two curative treatments for patients with laryngeal cancer (LC). RT has the advantage that it offers a possibility to preserve a functioning larynx and hence a functioning normal ... -
The role of p53 in tumor progression and prognosis in patients with primary colorectal cancer
(2001)Mutation in TP53 is the most common genetic alteration in human cancer. Alterations in p53 has mostly been related to poor prognosis in colorectal cancer, but this observation has not always been confirmed. The aim of the ... -
Transcriptional Regulation ofthe Platelet-Derived Growth Factor beta-receptor
(2004)The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses ... -
Tumor biological aspects of the mucin-like glycoprotein CD43
(2005)Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. CD43, a type I transmembrane protein, is a ... -
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ...