Browsing by Subject "B cells"
Now showing items 1-11 of 11
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Activation of mononuclear cells from blood and lung by Streptococcus pneumoniae and Haemophilus influenzae
(1998)The response of human peripheral blood mononuclear cells (PBMC) to stimulation with whole killed S. pneumoniae or H. influenzae is not very well characterised. The aim of the present study was to investigate the proliferative ... -
Approaches to analyses of cytotoxic cells. And studies of their role in H. pylori infection
(2005)Helicobacter pylori infection causes chronic gastritis that may progress to peptic ulcers or gastric adenocarcinoma and thereby cause major world-wide health problems. Previous studies have shown that CD4+ T cells and the ... -
B cell subpopulations in the pathogenesis of rheumatoid arthritis
(2019-04-04)B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG ... -
The B lymphocyte in Staphylococcus aureus arthritis
(2003)Joint infection caused by Staphylococcus aureus leads to heavy synovitis and rapid destruction of bone and cartilage. Permanent loss of joint function is seen in 20-50% of the patients, despite early eradication of the ... -
Commensal microbes, immune reactivity and childhood inflammatory bowel disease
(2009-06-29)Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories ... -
CTA1-DD; A novel vaccine adjuvant system based on ADP-ribosyltransferase activity and B cell targeting
(2000)The ADP-ribosylating enterotoxins, cholera toxin (CT) and E. coli heat-labile toxin (LT) are among the most powerful immunogens and adjuvants yet described. An innate problem, though, is their strong toxic effects, largely ... -
Functional analysis of the -1087 single nucleotide polymorphism in the IL-10 promoter region.
(2010-11-15)Interleukin (IL) 10 is recognized as a pro-inflammatory cytokine that promotes B cell proliferation. The objectives of the present series of studies were to analyze (i) differences in transcription factor binding to the ... -
Immune regulation by selective estrogen receptor modulators
(2015-04-30)At menopause, the levels of estrogen decline, leading to loss of estrogen-mediated protective effects on bone and an increased risk of osteoporosis. Hormone replacement therapy, containing estrogen, has been used for many ... -
Immunomodulation by estrogen and estren
(2007-03-02)Estrogen affects the development and regulation of the immune system. Treatment of gonadectomized mice with estrogen results in suppression of T and B lymphopoiesis, as well as decreased delayed type hypersensitivity ... -
The role of B cells in rheumatoid arthritis
(2012-03-26)It has been known for a long time that B cells play a role in rheumatoid arthritis (RA). By production of autoantibodies, presentation of auto-antigens and by producing cytokines B cells may contribute to the pathogenesis ... -
Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles
(2019-04-23)This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a ...