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Studies on the Expression and Regulation of Enterotoxins and Colonization Factors in Enterotoxigenic Escherichia coli (ETEC)

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Title: Studies on the Expression and Regulation of Enterotoxins and Colonization Factors in Enterotoxigenic Escherichia coli (ETEC)
Authors: Nicklasson, Matilda
Issue Date: 28-Feb-2008
University: University of Gothenburg. Sahlgrenska Academy
Institution: Inst of Biomedicine. Dept of Medical Microbiology and Immunology
Parts of work: I Sjöling Å, Qadri F, Nicklasson M, Ara Begum Y, Wiklund G, Svennerholm AM. In vivo expression of the heat stable (estA) and heat labile (eltB) toxin genes of enterotoxigenic Escherichia coli (ETEC). Microbes and Infection 8 (2006) 2797-2802.

II Sjöling Å, Nicklasson M, Stenberg J, Eriksson S. Gene expression, translation and secretion of the heat stable (ST) and heat labile (LT) toxins of enterotoxigenic Escherichia coli (ETEC) are regulated in response to different external stimuli present in the gastrointestinal tract. Submitted for publication.

III Nicklasson M, Sjöling Å, Qadri F, Svennerholm AM. Gene and protein expression of colonization factors CS5 and CS6 in enterotoxigenic Escherichia coli (ETEC) after growth under different conditions in vitro and in vivo. In manuscript.

IV Nicklasson M, Sjöling Å, Lebens M, Tobias J, Janzon A, Brive L, Svennerholm AM. Mutations in the periplasmic chaperone leading to loss of surface expression of the colonization factor CS6 in enterotoxigenic Escherichia coli (ETEC) clinical isolates. Accepted for publication in Microbial Pathogenesis.

V Nicklasson M, Klena J, Rodas C, Bourgeois A, Torres O, Svennerholm AM, Sjöling Å. Genetic relationship of enterotoxigenic Escherichia coli ST/CS6 strains isolated from children living in Guatemala and adult visitors to Central America. Submitted for publication.
Disputation: Akademisk avhandling som för avläggande av medicine doktorsexamen vid Sahlgrenska Akademin vid Göteborgs universitet kommer att försvaras offentligt i hörsal ”Arvid Carlsson”, Academicum, Medicinaregatan 3, Göteborg, torsdagen den 31 januari 2008, kl 9.00
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: ETEC
heat-stable enterotoxin
heat-labile enterotoxin
colonization factors
virulence gene expression
in vivo and in vitro
genetic variability
Abstract: Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of acute watery diarrhoea in developing countries, particularly among local children less than five years and is also the most common cause of diarrhoea in travellers to ETEC endemic areas. The infection is transmitted by ingestion of contaminated food and water and the disease is established in the small intestine. Colonization factors (CFs) on the bacterial surface mediate adhesion to the intestinal epithelium and diarrho... more
ISBN: 978-91-628-7389-9
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet



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