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Vascular Wall Responses to Bypass Grafting - Studies in Mice

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Title: Vascular Wall Responses to Bypass Grafting - Studies in Mice
Authors: Österberg, Klas
Issue Date: 18-Jan-2008
University: Göteborg University. Sahlgrenska Academy
Institution: Inst of Medicine. Dept of Molecular and Clinical Medicine
Parts of work: I. Österberg K, Mattsson E. Intimal hyperplasia in mouse vein grafts is regulated by flow. J Vasc Res. 2005 Jan-Feb;42(1):13-20.

II. Fogelstrand P, Österberg K, Mattsson E. Reduced neointima in vein grafts following a blockage of cell recruitment from the vein and the surrounding tissue. Cardiovasc Res. 2005 Aug 1;67(2):326-32.

III. Österberg K, Mattsson E. Smooth muscle cells in mouse vein grafts are not recruited from the adjacent artery. In manuscript

IV. Österberg K, Andersson I, Gradin K, Bergström G, Mattsson E. Progenitor smooth muscle cells have limited ability to regenerate arterial function and morphology. In manuscript
Disputation: Aulan Sahlgrenska Universitetssjukhuset 20080208 Kl. 13.00
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Intimal hyperplasia
graft stenosis
smooth muscle cells
cellular recruitment
Abstract: Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia (IH). It is assumed that exaggerated intimal thickening is initiated by vessel wall injuries or local flow disturbances. Accumulation and proliferation of smooth muscle cells (SMCs) are key events in the formation of IH. It has been an established opinion that these cells ha... more
ISBN: 978-91-628-7314-1
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för medicin
Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet



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