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Improved bioenergetic recovery during experimental ischemia and reperfusion by irradiation


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/7505

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Thesis Lindgard.pdfThesis frame734KbAdobe PDF
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Spikblad Lindgard.pdfAbstract36KbAdobe PDF
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Delarbete III.pdfPaper III128KbAdobe PDF
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Title: Improved bioenergetic recovery during experimental ischemia and reperfusion by irradiation
Authors: Lindgård, Ann
E-mail: ann@wlab.gu.se
Issue Date: 16-Nov-2007
University: Göteborg University. Sahlgrenska Academy
Institution: Inst of Clincial Sciences. Dept of Surgery
Parts of work: I. Lindgård A., Lundberg J., Rakotonirainy O., Elander A. and Soussi B. Preservation of rat skeletal muscle energy metabolism by illumination. Life Sciences 72 (23), 2649-2658, 2003.
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II. Lundberg J., Lindgård A., Elander A. and Soussi B. Improved energetic recovery of skeletal muscle in response to ischemia and reperfusion injury followed by in vivo 31P-Magnetic Resonance Spectroscopy. Microsurgery 22 (4), 158-164, 2002.
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III. Lukes D., Lundgren A., Wilton J., Lindgård A., Omerovic E., Rakotonirainy O., Parra AK., Olausson M. and Soussi B. Singlet Oxygen Energy illumination during ischemia preserves high energy phosphates in a concordant heart xenotransplantation model. Laser Physics 13 (1), 84-90, 2003.
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IV. Lindgård A., Hultén LM., Svensson L. and Soussi B. Irradiation at 634 nm releases nitric oxide from human monocytes. Lasers in Medical Science 22(1), 30-36, 2007.
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Disputation: Akademisk avhandling som för avläggande av medicine doktorsexamen vid Sahlgrenska akademin vid Göteborgs Universitet kommer att offentligen försvaras i hörsalen Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg, fredagen den 7 december, kl. 13.00.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: energy metabolism
skeletal muscle
monocyte
ischemia
reperfusion
NMR
singlet oxygen energy
light
LED
Abstract: Prolonged ischemia and reperfusion frequently occur during clinical operations. The bioenergetic status decreases during ischemia and reactive oxygen species (ROS) are formed during reperfusion, which may lead to irreversible tissue injury. During prolonged ischemia, such as in complex microsurgical operations, tissue injury should be minimized to improve the chance of full recovery and function. Irradiation has previously been shown to improve functional recovery of cold-stored rat hearts via c... more
ISBN: 978-91-628-7294-6
URI: http://hdl.handle.net/2077/7505
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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