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Alzheimer’s Disease: effect of Tau-related genes on the pathology, neurochemistry and risk of disease

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Title: Alzheimer’s Disease: effect of Tau-related genes on the pathology, neurochemistry and risk of disease
Authors: Sjölander, Annica
Issue Date: 7-Nov-2007
University: Göteborg University. Sahlgrenska Academy
Institution: Inst of Neuroscience and Physiology. Dept of Psychiatry and Neurochemistry
Parts of work: I. Johansson A, Hampel H, Faltraco F, Buerger K, Minthon L, Bogdanovic N, Sjogren M, Zetterberg H, Forsell L, Lilius L, Wahlund LO, Rymo L, Prince JA, and Blennow K. “Increased frequency of a new polymorphism in the cell division cycle 2 (CDC2) gene in patients with Alzheimer's disease and frontotemporal dementia” Neuroscience Letters 2003 April 340 (1) 69-73.

II. Johansson A, Zetterberg H, Håkansson A, Nissbrandt H and Blennow K. “TAU haplotype and Saitohin Q7R gene polymorphism do not influence cerebrospinal fluid levels of tau and β-amyloid1-42, in Alzheimer’s disease and frontotemporal dementia” Neurodegenerative Disorders 2005 2 (1) 28-35.

III. Johansson A, Zetterberg H, Hampel H, Buerger K, Prince J, Minthon L, Wahlund LO and Blennow K. “Genetic association of CDC2 with CSF tau in Alzheimer’s disease” Dementia and Geriatric Cognitive Disorders 2005 20 (6) 367-374.

IV Sjölander A, Andersson M, Zetterberg H, Minthon L, Bogdanovic N and Blennow K. “The CDK5 gene and effect on CSF biomarkers and neuropathology in Alzheimer’s disease” Manuscript 2007.
Disputation: Fredagen den 16 november 2007, kl 13.30 i psykiatriklinikens aula (V-aula), Sahlgrenska Universitetssjukhuset/Mölndal
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Abstract: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The predominant sporadic form of AD is a genetically complex disorder probably involving a combination of genetic factors together with environmental influences. To date, the best established genetic risk factor identified is the APOE ε4 allele. However not all AD cases have the APOE ε4 allele, thus several susceptibility genes remain to be found. One of the characteristics of AD is the intraneuronal accumulation of neu... more
ISBN: 978-91-628-7329-5
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet



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