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Atrial fibrillation in aging; methodological aspects and the relation to dementia and cerebral vascular disease

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Title: Atrial fibrillation in aging; methodological aspects and the relation to dementia and cerebral vascular disease
Authors: Lina, Rydén
Issue Date: 12-Jan-2022
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Rydén L*, Wetterberg H*, Ahlner F, Falk Erhag H, Gudmundsson P, Guo X, Joas E, Johansson L, Kern S, Mellqvist Fässberg M, Najar J, Ribbe M, Sacuiu S, Samuelsson J, Sigström R, Skoog J, Rydberg Sterner T, Waern M, Zettergren A, Skoog I. Attrition in the Gothenburg H70 Birth Cohort Studies -an 18-year follow-up of the 1930-cohort. *LR and HW are joint first authors

II. Rydén L, Sigström R, Nilsson J, Sundh V, Falk Erhag H, Kern S, Waern M, Östling S, Wilhelmson K, Skoog I. Agreement between self-reports, proxy-reports and the National Patient Register regarding diagnoses of cardiovascular disorders and diabetes mellitus in a population-based sample of 80-year-olds. Age and ageing. 2019:48(4):513-518.

III. Rydén L, Zettergren A, Seidu N M, Guo X, Kern S, Blennow K, Zetterberg H, Sacuiu S, Skoog I. Atrial fibrillation increases the risk of dementia amongst older adults even in the absence of stroke. Journal of Internal Medicine. 2019:286(1):101-110.

IV. Rydén L, Sacuiu S, Wetterberg H, Najar J, Guo X, Kern S, Zettergren A, Shams S, Pereira JB, Wahlund LO, Westman E, Skoog I. Atrial fibrillation, stroke and silent cerebrovascular disease: A population-based MRI study. Neurology. 2021;97(16):e1608-e1619.

Date of Defence: 2022-02-04
Disputation: Fredagen den 4 februari 2022, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: atrial fibrillation
silent brain infarcts
white matter hyperintensity
cerebral microbleed
small vessel disease
Abstract: Emerging evidence suggest an increased risk of dementia in individuals with atrial fibrillation (AF). However, until recently, few studies have investigated the relation between AF and dementia taking both prevalent and incident stroke into account. Therefore, this thesis aims to examine if AF increase the risk of dementia in a sample free from a history of stroke at baseline and incident stroke during follow-up. Further, the mechanisms behind an association between AF and dementia in the absenc... more
ISBN: 978-91-8009-574-7 (PRINT)
978-91-8009-575-4 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi



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