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Predictors of bone fragility in older women. Associations in older women between risk medications and measurements of physical function, bone microstructure and fracture risk


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Title: Predictors of bone fragility in older women. Associations in older women between risk medications and measurements of physical function, bone microstructure and fracture risk
Authors: Larsson, Berit
E-mail: berit.larsson.2@gu.se
Issue Date: 20-Dec-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Clinical Nutrition
Parts of work: 1. Larsson B, Mellström D, Johansson L, Nilsson A G, Lorentzon M, Sundh D. Normal Bone Microstructure and Density But Worse Physical Function in Older Women Treated with Selective Serotonin Reuptake Inhibitors, a Cross-Sectional Population-Based Study. Calcified Tissue International
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II. Larsson B A M, Sundh D, Mellström D, Axelsson K F, Nilsson A G, Lorentzon M. Association Between Cortical Bone Microstructure and Statin Use in Older Women. Journal of Clinical Endocrinology and Metabolism, 2019. Feb 1;104(2):250-257.
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III. Larsson B A M, Johansson L, Johansson H, Axelsson K F, Harvey N, Vandenput L, Magnusson P, McCloskey E, Liu E, Kanis JA, Sundh D, Lorentzon M. The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density. Osteoporosis International, 2021. Jan;32(1):75-84.
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IV. Larsson B A M, Johansson L, Johansson H, Axelsson K F, Harvey N, Vandenput L, McCloskey E, Liu E, Sundh D, Kanis J A, Lorentzon M. One leg standing time predicts fracture risk in older women independent of clinical risk factors and BMD. Osteoporosis International, 2021. Sep 8.
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Date of Defence: 2022-01-28
Disputation: Fredagen den 28 januari 2022, kl. 9.00, Mölndalsaulan, Mölndals sjukhus, SU/M, Göteborgsvägen 31, Mölndal
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: osteoporosis
risk prediction
fracture
risk medication
selective serotonin reuptake inhibitors
statins
physical function
timed up and go
one leg standing test
Abstract: Bone fragility with fractures constitutes a growing public health concern, resulting in suffering and major health care cost. This thesis project has been carried out by means of studies based on the SUPERB cohort of 75–80-year-old women from Gothenburg. Bone fragility has been addressed in relation to the commonly used selective serotonin reuptake inhibitors (SSRIs) and statins, as well as in relation to physical functional ability, measured using TUG (timed up and go) and OLST (one leg stand-... more
ISBN: 978-91-8009-522-8 (PRINT)
978-91-8009-523-5 (PDF)
URI: http://hdl.handle.net/2077/69809
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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