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On the efficacy and prescription of serotonin reuptake inhibitors

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Title: On the efficacy and prescription of serotonin reuptake inhibitors
Authors: Lisinski, Alexander
Issue Date: 9-Sep-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: 1. Hieronymus, F., Lisinski, A., Nilsson, S., Eriksson, E. (2019). Influence of baseline severity on the effects of SSRIs in depression: an item-based, patient-level post hoc analysis. Lancet Psych;6(9):745-752.

2. Lisinski, A., Hieronymus, F., Näslund, J., Nilsson, S., Eriksson, E. (2020). Item-based analysis of the effects of duloxetine in depression: a patient-level post hoc study. Neuropsychopharmacology 2020;45(3):553-560.

3. Lisinski, A., Hieronymus, F., Nilsson, S., Eriksson, E. (2021). Impact of chosen cut-off on response rate differences between selective serotonin reuptake inhibitors and placebo. Submitted.

4. Lisinski, A., Hieronymus, F., Nilsson, S., Eriksson, E. (2021). Item-based comparison of the tricyclic antidepressant amitriptyline and the selective serotonin reuptake inhibitor sertraline with respect to antidepressant efficacy: a patient-level, post-hoc study. Preliminary manuscript.

5. Lisinski, A., Hieronymus, F., Eriksson, E., Wallerstedt, S.M. (2021). Low SSRI dosing in clinical practice - a register-based longitudinal study. Acta Psychiatr Scand. 2021;143(5):434-443.

Date of Defence: 2021-10-01
Disputation: Fredagen den 1 oktober 2021, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: antidepressants
antidepressive agents
major depressive disorder
selective serotonin reuptake inhibitor
serotonin and noradrenaline reuptake inhibitor
tricyclic antidepressant
Abstract: This thesis addresses several controversial issues regarding commonly used antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs). To this end, patient-level data from 28 placebo-controlled trials on SSRIs and 13 corresponding trials on the SNRI duloxetine, were requested and obtained. Data from Swedish nation- or region-wide registers were also utilised. Questions addressed include... more
ISBN: 978-91-8009-458-0 (PRINT)
978-91-8009-459-7 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi



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