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T cells and chemokines in rheumatoid arthritis

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Title: T cells and chemokines in rheumatoid arthritis
Authors: Aldridge, Jonathan
Issue Date: 18-Aug-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Rheumatology and Inflammation Research
Parts of work: 1. Aldridge J, Pandya JM, Meurs L, Andersson K, Nordström I, Theander E, Lundell AC, and Rudin A. (2018). Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis patients. Arthritis Research & Therapy, 1:150.

2. Aldridge J, Andersson K, Gjertsson I, Hultgård- Ekwall AK, Hallström M, van Vollenhoven R, Lundell AC, and Rudin A. (2021). Blood PD-1+TFh and CTLA-4+CD4+ T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis. Rheumatology (Oxford), e-published before print.

3. Aldridge J, Lundell AC, Andersson K, Mark L, Lund Hetland M, Østergaard M, Uhlig T, Schrumpf Heiberg M, A. Haavardsholm E, Nurmohamed M, Lampa J, Nordström D, Hørslev-Petersen K, Gudbjornsson B, Gröndal G, van Vollenhoven R, and Rudin A. Blood chemokine levels are markers of disease activity but not predictors of remission in early rheumatoid arthritis. Submitted manuscript.

4. Aldridge J, Hultgård-Ekwall AK, Mark L, Bergström B, Andersson K, Gjertsson I, Lundell AC, and Rudin A. (2020). T helper cells in synovial fluid of patients with rheumatoid arthritis primarily have a Th1 and a CXCR3+Th2 phenotype. Arthritis Research & Therapy, 1:245.

Date of Defence: 2021-09-10
Disputation: Fredagen den 10 september 2021, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Rheumatoid arthritis
CD4+ T cells
disease activity
Abstract: In this thesis, we investigated if circulating proportions of specific CD4+ T cell subsets and blood chemokine levels were associated with disease activity and/or could predict remission in patients with early rheumatoid arthritis (eRA). We also compared the effect of different biological treatments on both T cell subset proportions and chemokine levels. Finally, we examined which T helper cell subsets are most abundant in the synovial fluid of inflamed joints, and which T cell associated ... more
ISBN: 978-91-8009-416-0 (PRINT)
978-91-8009-417-7 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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