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Principles of scaffold generation for bioengineering of the ovary and uterus: a study focusing on decellularization


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Title: Principles of scaffold generation for bioengineering of the ovary and uterus: a study focusing on decellularization
Authors: Alshaikh, Ahmed Baker
E-mail: ahmed.alshaikh@gu.se
Issue Date: 27-May-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Obstetrics and Gynecology
Parts of work: I. AB Alshaikh, AM Padma, M Dehlin, R Akouri, MJ Song, M Brännström, M Hellström. Decellularization of the mouse ovary: comparison of different scaffold generation protocols for future ovarian bioengineering. J. Ovarian Res. 2019; 12:58.
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II. AB Alshaikh, AM Padma, M Dehlin, R Akouri, MJ Song, M Brännström, M Hellström. Decellularisation and recellularisation of the ovary for bioengineering applications: Studies in the mouse. Reprod Biol Endocrinol. 2020 Jul 23;18(1):75.
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III. Padma AM, Alshaikh AB, Song MJ, Akouri R, Oltean M, Brännström M, Hellström M. Decellularisation protocol-dependent DAMPs in rat uterus scaffolds differentially activate the immune response after transplantation. Manuscript under revision for Journal of Tissue Engineering and Regenerative Medicine.

IV. Padma AM, Alshaikh AB, Song MJ, Akouri R, Akyürek L, Oltean M, Brännström M, Hellström M. Immune response after allogeneic transplantation of decellularized uterine scaffolds in the rat. Biomed Mater. Under 2nd revision
Date of Defence: 2021-06-18
Disputation: Fredagen den 18 juni 2021, kl.13.00, Carl Kylberg, Medicinaregatan 9, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: uterus
ovary
decellularization
recellularization
infertility
tissue engineering
Abstract: Introduction: Cancer therapy often result in fertility problems due to inflicted injury to the reproductive organs. Since most women survive cancer, fertility preservation has become an important consideration during cancer therapy. However, options for young women with blood-related cancers are missing. Papers I-II describe the development and characterization of mouse ovarian scaffolds derived from ovarian extracellular ma-trix (ECM). Such scaffolds may be used for future ovarian bioengineerin... more
ISBN: 978-91-8009-356-9 (PRINT)
978-91-8009-357-6 (PDF)
URI: http://hdl.handle.net/2077/68068
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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