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On osseointegration in response to controlled surface nanotopography

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Title: On osseointegration in response to controlled surface nanotopography
Authors: Karazisis, Dimitrios
Issue Date: 20-May-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Biomaterials
Parts of work: I. Karazisis D, Ballo AM, Petronis S, Agheli H, Emanuelsson L, Thomsen P, Omar O. The role of well-defined nanotopography of titanium implants on osseointegration: cellular and molecular events in vivo. Int J Nanomedicine. 2016;11:1367-82.

II. Karazisis D, Petronis S, Agheli H, Emanuelsson L, Norlindh B, Johansson A, Rasmusson L, Thomsen P, Omar O. The influence of controlled surface nanotopography on the early biological events of osseointegration. Acta Biomater. 2017;53:559-571.

III. Karazisis D, Rasmusson L, Petronis S, Palmquist A, Furqan A. Shah FA, Agheli H, Emanuelsson L, Johansson A, Omar O, Thomsen P. The effects of controlled nanotopography, machined topography and their combination on the molecular activities, bone formation and biomechanical stability during osseointegration. Manuscript Submitted.

IV. Karazisis D, Omar O, Petronis S, Thomsen P, Rasmusson L. The molecular response to nanopatterned implants in human jaw bone. Manuscript Submitted.
Date of Defence: 2021-06-11
Disputation: Fredagen den 11 Juni 2021, kl 13.00, Föreläsningssalen, Biotech Center, Arvids Wallgrens Backe 20, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: in vivo
Abstract: Knowledge about the biological responses provoked by the surface modification of titanium implants on the nanoscale is still in its infancy. Although in vitro studies claim superior effects considering higher adhesion and proliferation of osteoblasts in the short term and even differentiation towards the osteogenic cell lineage in the long term, these responses do not necessarily reflect the actual outcome in the complex in vivo environment. Therefore, the main aim of this thesis was to evaluate... more
ISBN: 978-91-8009-344-6 (PRINT)
978-91-8009-345-3 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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