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Characterization of secretory mechanisms in lacrimal and salivary glands

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Title: Characterization of secretory mechanisms in lacrimal and salivary glands
Authors: Dankis, Martin
Issue Date: 25-Mar-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: I. Johnsson M., Winder M., Zawia H., Lödöen I., Tobin G., Götrick B. In vivo studies of effects of antidepressants on parotid salivary secretion in the rat. Arch Oral Biol. 67:54-60.

II. Dankis M., Aydogdu Ö., Tobin G., Winder M. Inhibitory effects of antidepressants on lacrimal gland secretion in the anaesthetized rat. Preliminary manuscript

III. Dankis M., Carlsson T., Aronsson P., Tobin G., Winder M. Novel insights into the function of muscarinic and purinergic receptors in primary cultures of rat lacrimal gland myoepithelial cells. Preliminary manuscript

IV. Dankis M., Aronsson P., Carlsson T., Tobin G., Winder M. Functional muscarinic and purinergic responses in primary co-cultures of rat lacrimal gland myoepithelial and acinar cells. Preliminary manuscript
Date of Defence: 2021-04-15
Disputation: Torsdagen den 15 april 2021, kl 13.00, Rum 2119, Hälsovetarbacken, Hus 2, Arvid Wallgrens backe,Göteborg
Degree: Doctor of Philosophy (Pharmaceutical science)
Publication type: Doctoral thesis
Keywords: dry mouth
dry eyes
salivary secretion
tear secretion
lacrimal gland
in vivo
primary culture
Abstract: Dry mouth and dry eyes are multifactorial morbidities that can lead to a severely reduced quality of life. Approximately 20% of the population suffers from ocular or oral dryness. In the pursuit of pharmacological treatments of these troublesome symptoms, we sought to identify new targets and characterize underlying mechanisms that modulate lacrimal and salivary secretion. Xerogenic and xerophthalmic effects of antidepressants were examined in a rat in vivo model. Centrally mediated secretion ... more
ISBN: 978-91-8009-218-0 (PRINT)
978-91-8009-219-7 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi



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