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Revealing the architecture and composition of the sperm flagellum tip


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/67318

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Title: Revealing the architecture and composition of the sperm flagellum tip
Authors: Zabeo, Davide
E-mail: davide.zabeo@gu.se
Issue Date: 25-Jan-2021
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: Davide Zabeo, Jacob T Croft, Johanna L Höög. Axonemal doublet microtubules can split into two complete singlets in human sperm flagellum tips. FEBS Lett, 593: 892-902 (2019).
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Davide Zabeo, John M Heumann, Cindi L Schwartz, Azusa Suzuki-Shinjo, Garry Morgan, Per O Widlund, Johanna L Höög. A luminal interrupted helix in human sperm tail microtubules. Sci Rep, 8, 2727 (2018).
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Jacob T Croft*, Davide Zabeo*, Vajradhar Acharya, Václav Bočan, Mandy Rettel, Matthew C Johnson, Frank Stein, Christer Edvardsson, Lenka Libusová, Mikhail Savitski, Per O Widlund, Radhika Subramanian, Justin M Kollman, Johanna L Höög. *These authors contributed equally to the manuscript. Identification and biochemical characterization of TAILS: a microtubule inner complex. Unpublished manuscript (2021).
Date of Defence: 2021-03-12
Disputation: Fredagen den 12 mars 2021 kl. 15:00 i hörsalen 2119 Hälsovetarbacken, Arvid Wallgrens backe hus 2, Göteborg
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Cell biology
Structural biology
Microtubules
Electron microscopy
Cryo-electron microscopy
Cryo-electron tomography
Abstract: The eukaryotic flagellum is a membrane-bound protruding organelle with a cytoskeleton of microtubules. Flagella are found in unicellular as well as multicellular organisms, performing a variety of functions. Motile flagella enable cell locomotion, like in protists or spermatozoa, but can also create flows of fluids or mucus, like in respiratory airways. Flagella also act as cellular “antennas”, as their surface can probe the environment with sensorial receptors. The flagellar ultrastructure is o... more
URI: http://hdl.handle.net/2077/67318
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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