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The role of MBOAT7 on fatty liver disease

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Title: The role of MBOAT7 on fatty liver disease
Authors: Caddeo, Andrea Marco
Issue Date: 18-Feb-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Caddeo A*, Jamialahmadi O*, Solinas G, Pujia A, Mancina RM, Pingitore P, Romeo S. MBOAT7 is anchored to endomembranes by six transmembrane domains. J Struct Biol. 2019 Jun 1;206(3):349-360. Epub Apr 5. 2019

II. Caddeo A, Hedfalk K, Romeo S, Pingitore P. LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol Biochim. Biophys. Acta, Mol. Cell. Biol. Lipids 2021 Jan 26;158891,

III. Tanaka Y*, Shimanaka Y*, Caddeo A*, Kubo T, Mao Y, Kubota T, Kubota N, Yamauchi T, Mancina RM, Baselli G, Luukkonen P, Pihlajamäki J, Yki-Järvinen H, Valenti L, Arai H, Romeo S, Kono N. LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover Gut. 2020 Apr 6. pii: gutjnl-2020-320646

Date of Defence: 2021-03-19
Disputation: Fredagen den 19 mars 2021, kl. 09.00, Hjärtats Aula, Blå Stråket 5, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Liver disease
Abstract: Non-alcoholic fatty liver disease (NAFLD) is the main health disorder in internal medicine, affecting one third of the population worldwide. Environmental and genetic factors contribute to NAFLD susceptibility and progression. Amongst these, a genetic variant in the membrane bound O-acyltransferase domain-containing 7 (MBOAT7), also known as lysophosphatidylinositol acyltransferase 1 (LPIAT1), robustly contributes to the entire spectrum of NAFLD. MBOAT7 encodes for an O-acyltransferase that c... more
ISBN: 978-91-8009-173-2 (PDF)
978-91-8009-172-5 (PRINT)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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