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A Holistic View on Aquaporins: Production, Structure, Function and Interactions


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Titel: A Holistic View on Aquaporins: Production, Structure, Function and Interactions
Författare: Schmitz, Florian
E-post: countdooky@gmail.com
Utgivningsdatum: 21-okt-2020
Universitet: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Delarbeten: 1. Schmitz F, Luthman K, Jarho E, Hedfalk K, Seifert T (2020) Efficient production of pure and catalytically active SIRT2 in Pichia pastoris, Manuscript (not submitted)

2. Zeng J, Schmitz F, Isaksson S, Arbab O, Andersson M, Sundell K, Eriksson L, Swaminathan K, Törnroth-Horsefield S, Hedfalk K (2020) Novel structural mechanism of extracellular gating of aquaporin from the fish climbing perch (Anabas testudineus), Manuscript (not submitted)

3. Wang H, Schoebel S, Schmitz F, Dong H, Hedfalk K (2020) Characterization of aquaporin-driven hydrogen peroxide transport. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1862(2), 183065,
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4. Wang H, Schoebel S, Schmitz F, Dong H, Hedfalk K (2020) Quantitative analysis of H2O2 transport through purified membrane proteins. MethodsX, 7, 100816,
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5. Schmitz F*, Glas J*, Neutze R, Hedfalk K (2020) High-throughput screening combining bimolecular fluorescence with flow cytometry reveals constructive membrane protein complex formation, Manuscript (not submitted)
Datum för disputation: 2020-11-20
Disputation: Fredagen den 11 november 2020, kl 10.00, Hörsal Carl Kylberg, Medicinaregatan 7.
Examinationsnivå: Doctor of Philosophy
Publikationstyp: Doctoral thesis
Nyckelord: aquaporin
membrane proteins
protein interactions
functional studies
Sammanfattning: Aquaporins are specialised membrane proteins, which regulate the water homeostasis of cells. In eukaryotic organisms, this process is tightly regulated, and aberrations in aquaporin functionality lead to severe pathologies in humans. The aim of this thesis is to shed light on the aquaporin function and regulation, both as individual protein targets and in the cellular context, as well as exploring various applications for human aquaporin 4, specifically. A wide range of biochemical methods have ... mer
ISBN: 978-91-8009-068-1
URI: http://hdl.handle.net/2077/66539
Samling:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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