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Serotonin in Fear and Anxiety

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Title: Serotonin in Fear and Anxiety
Authors: Hagsäter, Melker
Issue Date: 16-Oct-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: I. Hagsäter SM, Pettersson R, Holmäng A and Eriksson E, “Serotonin depletion reduces both acquisition and expression of context-conditioned fear”, Submitted

II. Hagsäter SM, Pettersson R, Pettersson C, Atanasovski D, Näslund J and Eriksson E, “A complex impact of the 5-HT2A receptor on conditioned fear revealed by systemic administration of different 5-HT2A ligands including pimavanserin and psilocybin”, Submitted

III. Pettersson R, Hagsäter SM, Carlsson B, Karlsson L and Eriksson E, “Chronic but not acute administration of escitalopram reduces context-conditioned fear”, Submitted

IV. Hagsäter SM, Thorén J, Pettersson R and Eriksson E, “Selective serotonin reuptake inhibition increases noise burst-induced unconditioned and context conditioned freezing”, Acta Neuropsychiatrica, 2019, 31, 46-51,

V. Hagsäter SM, Lisinski A and Eriksson E, “5-HT6 receptor antagonism reduces defecation in rat: A potential treatment strategy for irritable bowel syndrome with diarrhea”, European Journal of Pharmacology, 2019, 864, 172718,

Date of Defence: 2020-11-06
Disputation: Fredagen den 6 november 2020, kl. 13.00, Hörsal Carl Kylberg, Medicinaregatan 7B, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: serotonin
Abstract: That the neurotransmitter serotonin (5-HT) has a central role in fear and anxiety is supported by numerous experimental and clinical studies. Arguably the most illustrative example is the effect of serotonergic-acting drugs, and in particular the selective serotonin reuptake inhibitors (SSRIs), in the treatment of anxiety disorders. Interestingly, long-term administration is required to induce a dampening effect on anxiety, while on the contrary acute administration can aggravate the sympto... more
ISBN: 978-91-8009-001-8 (PDF)
978-91-8009-000-1 (PRINT)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi



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