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A Podocyte view on RhoGTPases and actin cytoskeleton regulation

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Title: A Podocyte view on RhoGTPases and actin cytoskeleton regulation
Authors: Bergwall, Lovisa
Issue Date: 11-Jun-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: I: Amplification of the Melanocortin-1 Receptor In Nephrotic Syndrome Identifies a Target for Podocyte Cytoskeleton Stabilization. Bergwall L, Wallentin H, Elvin J, Liu P, Boi R, Sihlbom C, Hayes K, Wright D, Haraldsson B, Nyström J and Buvall L. Scientific Reports (2018) 8 (1), 15731

II: Podocyte Geranylgeranyl transferase type I is essential for maintenance of the glomerular filtration barrier function. Bergwall L, Boi R, Akula M.K, Ebefors K, Bergo O.M, Nyström J, Buvall L. Manuscript.

The Role of Beta-pix in podocyte Rac1 activation and cytoskeleton rearrangement. Bergwall L, Wallentin H, Boi R, Svensk S, Lövljung V, Sihlbom C, Weins A, Ericsson A, William-Olsson L, Granqvist B. A, Ebefors K, Nyström J, Buvall L. Manuscript.
Date of Defence: 2020-09-04
Disputation: Fredagen den 4 september 2020, kl 9.00, Hjärtats Aula, Sahlgrenska Universitetssjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Podocyte
Actin cytoskeleton regulation
Abstract: Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice. Curative treatments for the underlying cause of disease are however lacking and treatments currently in use to induce disease remission are associated with unfavorable side effects. Dysregulation of the podocyte actin cytoskeleton underlies the pathological process called foot pro... more
ISBN: 978-91-7833-908-2 (PRINT)
978-91-7833-909-9 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi



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