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Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors


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Title: Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors
Authors: Mthembu, Yolanda Hlamazi
E-mail: yolanda.mthembu@gu.se
yolandamthembu@gmail.com
Issue Date: 11-Jun-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Laboratory Medicine
Parts of work: I. Mthembu YH , Jin C , Padra M, Liu J, Olofsson –Edlund J, Ma H, Padra J, Oscarson S, Borén T, Karlsson NG, Lindén SK and Holgersson J. Recombinant mucin-type proteins carrying LacdiNAc on different O-glycan core chains fail to support H. pylori binding. Molecular Omics
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II. Mthembu YH, Olofsson-Edlund J, Jin C, Cherian R, Liu J, Karlsson NG, Borén T, and Holgersson J. Identification of the O-glycomes of mucin-type receptors for BabA- and SabA-mediated Helicobacter pylori adhesion. Submitted.

III. Mthembu YH, Jin C, Padra M, Liu J, Karlsson NG, Linden SK and Holgersson J. O-glycan core chain specificity of A4GNT and the effect of GlcNAcα4Gal determinants on Helicobacter pylori growth. Manuscript.

IV. Flowers SA, Thomsson KA, Ali L, Huang S, Mthembu YH, Gallini R, Holgersson J, Schmidt TA, Rolfson O, Björkman LI, Sundqvist M, Karlsson-Bengtsson A, Jay G, Kamali-Moghaddam M, Eisler T, Krawetz R and Karlsson NG. Core-2 O-glycans are required for galectin-3 interaction with the osteoarthritis related protein lubricin. Submitted.
Date of Defence: 2020-09-04
Disputation: Fredagen den 4 september 2020, klockan 08.30, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: O-glycans
mucins
glycosyltransferases
Helicobacter pylori
microbial adhesion
Abstract: Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current antibiotic regimen used in the treatment to eradicate H. pylori fails in 20% of the patients. A multivalent glycan inhibitor could offer a suitable alternative to antibiotics by acting as a competitive inhibitor for the cell receptors, leading to the binding and elimination ... more
ISBN: 978-91-7833-946-4 (PRINT)
978-91-7833-947-1 (PDF)
URI: http://hdl.handle.net/2077/64540
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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