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Pathophysiology and treatment of Takotsubo Syndrome - insights from preclinical studies


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Title: Pathophysiology and treatment of Takotsubo Syndrome - insights from preclinical studies
Authors: Gasim Elsied, Anwar
E-mail: anwar.ali@wlab.gu.se
Issue Date: 3-Sep-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: 1.Redfors B, Ali A, Shao Y, Lundgren J, Omerovic E. Different catecholamines induce different patterns of Takotsubo-like cardiac dysfunction in an apparently afterload dependent manner. Int J Cardiol. 174 (2014) 330-336.
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2. Anwar Ali, Björn Redfors, Joel Lundgren, Jessica Alkhoury, Jonatan Oras, Li-Ming Gan, Omerovic E. Effects of pretreatment with cardiostimulants and beta-blockers on isoprenaline-induced Takotsubo-like cardiac dysfunction in rats. Int J Cardiol. 2019 Apr 15; 281:99-104.
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3. Anwar Ali, Björn Redfors, Joel Lundgren, Jessica Alkhoury, Jonatan Oras, Li-Ming Gan, Omerovic E. The role of heart rate in isoprenaline-induced takotsubo-like cardiac dysfunction in rats. Europ J Heart Fail. 2020 July 20.
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4. Anwar Ali, Björn Redfors, Jessica Alkhoury, Jonatan Oras, Li-Ming Gan, Omerovic E. Sacubitril/valsartan decreases mortality and attenuates development of apical akinesia in rat model of isoprenaline-induced Takotsubo-like syndrome. In manuscript.
Date of Defence: 2020-09-28
Disputation: Måndagen den 28 september 2020, kl. 13.00, Hörsal Arvid Carlsson, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Takotsubo
Abstract: ABSTRACT Background: Takotsubo syndrome (TTS), also recognized as “stress-induced cardiomyopathy (SIC)” and “broken heart syndrome”, is an acute cardiac failure syndrome characterized by transient regional ventricular akinesia or hypokinesia, and often presents similarly to acute myocardial infarction (AMI). In contrast to AMI, the characteristic regional myocardial akinesia in TTS does not involve a culprit coronary artery. Although the associated cardiac dysfunction is potentially reversible,... more
ISBN: 978-91-7833-980-8 (PRINT)
978-91-7833-981-5 (PDF)
URI: http://hdl.handle.net/2077/64524
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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