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The construction, analysis and validation of mechanistic mathematical models of protein kinetics in the context of replicative ageing in budding yeast


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Title: The construction, analysis and validation of mechanistic mathematical models of protein kinetics in the context of replicative ageing in budding yeast
Authors: Johannes, Borgqvist
E-mail: johborgq@chalmers.se
Issue Date: 4-May-2020
University: Göteborgs universitet. Naturvetenskapliga fakulteten
Institution: Department of Mathematical Sciences ; Institutionen för matematiska vetenskaper
Parts of work: Kappa: ISBN: 978-91-7833-911-2 (PDF),

Spikblad

Paper I: https://doi.org/10.1002/9783527696130.ch9

Paper II: https://doi.org/10.1038/s41598-020-58444-2

Paper III: https://doi.org/10.1101/2020.03.24.005116

Paper IV: https://doi.org/10.1101/2020.01.29.925628

Paper V: https://doi.org/10.1101/2020.01.27.922005
Date of Defence: 2020-06-12
Disputation: Fredagen den 12 juni 2020, kl. 10.15, Gustaf Dalénsalen, Chalmers Campus Johanneberg, Chalmers Tvärgata 5
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Protein kinetics
Replicative ageing
Cdc42
Ordinary differential equations
Reaction diffusion models
Parameter estimation
Model validation
Model construction
Symmetry methods
Abstract: Mathematical modelling constitutes a forceful tool for elucidating properties of biological systems. Using theoretical approaches in combination with experimental techniques it is possible to study specific molecular aspects of phenomena such as the ageing of human beings. In fact, as many processes are similar in simpler organisms such as the budding yeast \textit{Saccharomyces cerevisiae} it is possible to experimentally investigate for instance the accumulation of damaged proteins due to agei... more
ISBN: 978-91-7833-910-5
URI: http://hdl.handle.net/2077/64055
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för matematiska vetenskaper

 

 

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