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Biomarkers in mid-trimester amniotic fluid in relation to gestational duration and spontaneous preterm delivery

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Title: Biomarkers in mid-trimester amniotic fluid in relation to gestational duration and spontaneous preterm delivery
Authors: Hallingström, Maria
Issue Date: 15-May-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Obstetrics and Gynecology
Parts of work: I. Hallingström M, Cobo T, Kacerovský K, Skogstrand K, Hougaard DM, Holst RM, Tsiartas P, Bullarbo M, Carlsson Y, Nilsson S, Jacobsson B. The association between selected mid-trimester amniotic fluid candidate proteins and spontaneous preterm delivery. J Matern Fetal Neonatal Med. 2018 Sep 10:1-10.

II. Hallingström M, Lenčo J, Vajrychová M, Link M, Tambor V, Liman V, Bullarbo M, Nilsson S, Tsiartas P, Cobo T, Kacerovský M, Jacobsson B. Proteomic analysis of early mid-trimester amniotic fluid does not predict spontaneous preterm delivery. PLoS One. 2016 May 23;11(5).

III. F, Tancred L, Rabe H, Jonsson D, Kachikis A, Nilsson S, Kacerovský M, Adams Waldorf K, Jacobsson B. Mid-trimester amniotic fluid proteome’s association with spontaneous preterm delivery and gestational duration. Accepted for publication in PLoS One, April 2020.

IV. Viklund F*, Hallingström M*, Kacerovský M, Cobo T, Skogstrand K, Hougaard D M, Sävman K, Carlsson Y, Tsiartas P, Juodakis J, Nilsson S, Jacobsson B. Protein concentrations of thrombospondin-1, MIP-1β and S100A8 suggest the reflection of a pregnancy clock in mid-trimester amniotic fluid. Revision submitted to Reproductive Sciences, April 2020. * Equal contribution

V. Hallingström M*, Barman M*, Savolinen O, Viklund F, Kacerovský M, Brunius C*, Jacobsson B*. Metabolomic profiles of mid-trimester amniotic fluid are not associated with subsequent spontaneous preterm delivery or gestational duration at delivery. Revision submitted to Journal of Maternal-Fetal & Neonatal Medicine, April 2020. * Equal contribution
Date of Defence: 2020-06-05
Disputation: Fredagen den 5 juni 2020, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: amniotic fluid
damage-associated molecular pattern
gestational duration
pregnancy clock
spontaneous preterm delivery
term delivery
Abstract: Background: The biological mechanisms and physiological pathways of pregnancy maintenance and timing of delivery are complex and multifactorial. Pregnancy clocks, partly controlled by timing mechanisms linked to fetal development, which regulate the onset of labor has previously been described. These clocks include inflammatory processes, involving endocrine, mechanical and genetic factors. However, the sequence and timing of events preceding the spontaneous onset of labor, both at term and at p... more
ISBN: 978-91-7833-728-6 (PRINT)
978-91-7833-729-3 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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