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The impact of signaling factors on intervertebral disc degeneration and regeneration - studies on disc and mesenchymal stem cells from chronic low back pain patients


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Title: The impact of signaling factors on intervertebral disc degeneration and regeneration - studies on disc and mesenchymal stem cells from chronic low back pain patients
Authors: Hingert, Daphne
E-mail: daphne.hingert@gu.se
Issue Date: 19-May-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Orthopaedics
Parts of work: Hingert D, Barreto Henriksson H, Brisby H. Human Mesenchymal Stem Cells Pretreated with Interleukin-1β and Stimulated with Bone Morphogenetic Growth Factor-3 Enhance Chondrogenesis. Tissue Eng Part A. 2018 May; 24(9-10):775-785.
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Hingert D, Nilsson J, Barreto Henriksson H, Baranto A, Brisby H.. Pathological Effects of Cortisol on Intervertebral Disc Cells and Mesenchymal Stem Cells from Lower Back Pain Patients. Cells Tissues Organs. 2019;207(1):34-45.
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Hingert D, Barreto Henriksson H, Baranto A, Brisby H. BMP-3 Promotes Matrix Production in Co-cultured Stem Cells and Disc Cells from Low Back Pain Patients. Tissue Eng Part A. 2020 Jan; 26(1-2):4756.
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Hingert D, Nawilaijaroen P, Aldridge J, Baranto A, Brisby H: Investigation of the Effect of Secreted Factors from Mesenchymal Stem Cells on Disc Cells from Degenerated Discs. Cells Tissues Organs 2020.
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Hingert D, Nawilaijaroen P, Ekström K, Baranto A, Brisby H. Human levels of MMP-1 in degenerate discs can be mitigated by signaling peptides from mesenchymal stem cells. Submitted.

Hingert D, Ekström K, Aldridge J, Crescitelli R, Brisby H. Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures. Submitted.
Date of Defence: 2020-06-05
Disputation: Fredagen den 5 juni 2020, kl 9.00, R-Aulan, Sahlgrenska universitetssjukhuset/Mölndal
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Regenerative medicine
Translational medicine
Abstract: INTRODUCTION: Chronic low back pain (LBP) is associated with degeneration of the intervertebral discs (IVDs). Increased expressions of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and matrix metalloproteinases (MMPs) in degenerated IVDs lead to loss of proteoglycan and extracellular matrix (ECM) which affect the viability of the disc cells (DCs). Treatment approaches using growth factors, cell therapy and extracellular vesicles (EVs) derived from human mesenchymal stem cells (hMSCs)... more
ISBN: 978-91-7833-852-8 (PRINT)
978-91-7833-853-5 (PDF)
URI: http://hdl.handle.net/2077/63609
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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