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Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity


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Title: Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity
Authors: Molinaro, Angela
E-mail: angela.molinaro@wlab.gu.se
angela.molinaro@wlab.gu.se
Issue Date: 28-Apr-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: Breasson L.,Becattini B., Sardi C.,Molinaro A., Zani I. F.,Marone R.,Botindari F.,Bousquenaud M.,Ruegg C.,Wymann M. P.,Solinas G. PI3Kgactivity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Science Signaling. 2017 Jul 18;10(488)
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Molinaro A., Becattini B., Mazzoli A., Bleve A., Radici L., Maxvall I., Rotter Sopasakis V., Molinaro A., Bäckhed F., Solinas G. Insulin-driven PI3K-AKT signaling in the hepatocyte is Mediated by Redundant PI3Ka and PI3Kb Activities and is promoted by RAS. Cell Metabolism. 2019 Jun 4;29(6):1400- 1409.e5.
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Molinaro A., Becattini B. and Solinas G. Insulin Signaling and Glucose Metabolism in Different Hepatoma Cell Lines Deviate from Hepatocyte Physiology Toward a Convergent Aberrant Phenotype. Manuscript submitted and under revision.
Date of Defence: 2020-05-19
Disputation: Tisdagen den 19 maj 2020, kl. 9.00, Sal Carl Kylberg, Medicinaregatan 7, Göteborg https://gu-se.zoom.us/j/69610974478
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Obesity
insulin signaling
PI3Ks
PI3K isoform-selective inhibitors
Abstract: Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society. However, the mechanism that links obesity to these diseases remains largely unresolved. Class 1 phosphatidylinositide 3 kinases (PI3Ka; PI3Kb; PI3Kd and PI3Kg) play a major role in several physiological processes such as the immune response, the metabolic insulin action, and tissues homeostasis. This thesis aims at ... more
ISBN: 978-91-7833-864-1 (PRINT)
978-91-7833-865-8 (PDF)
URI: http://hdl.handle.net/2077/63280
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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