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On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/63276

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Title: On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis
Authors: Julia, Adelöf
E-mail: julia.adelof@gu.se
julia.adelof@gmail.com
Issue Date: 23-Apr-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Clinical Neuroscience and Rehabilitation
Parts of work: I: Adelöf J, Andersson M, Porritt M, Petersen A, Zetterberg M, Wiseman J, Hernebring M. PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity. BMC Neurosci. 2018 Nov 6;19(1):70.
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II: Adelöf J, Ross JM, Lazic SE, Zetterberg M, Wiseman J, Hernebring M. Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan. Aging (Albany NY). 2019 Sep 11;11(17):7150-7168.
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III. Hernebring M, Adelöf J, Wiseman J, Petersen A, Zetterberg M. H2O2-induced cataract as a model of age-related cataract: lessons learned from over-expressing the proteasome activator PA28αβ in mouse eye lens. Manuscript

IV. Adelöf J, Wiseman J, Zetterberg M, Hernebring M. PA28α overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age. Manuscript
Date of Defence: 2020-05-15
Disputation: Fredagen den 15 maj 2020, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg. https://gu-se.zoom.us/j/65963989874
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Aggregation prevention
Aging
Animal ethics
Cataract
Exploratory behavior
F2 hybrid mice
Healthy aging
Learning and memory
PA28αβ
Proteasome capacity
Sex comparisons
Water-based behavioral tests
Abstract: As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. PA28αβ has previously demonstrated protective effects against proteinopathy and is involved in removal of protein damage early in mammalian embryonic development. In this thesis project, female and male mice overexpressing PA28αβ have been followed and analyzed throughout t... more
ISBN: 978-91-7833-808-5 (PRINT)
978-91-7833-809-2 (PDF)
URI: http://hdl.handle.net/2077/63276
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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