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Hyperbaric oxygen treatment for pelvic radiation-induced injuries. From a multicenter randomized controlled trial to an experimental cell model

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Title: Hyperbaric oxygen treatment for pelvic radiation-induced injuries. From a multicenter randomized controlled trial to an experimental cell model
Authors: Oscarsson, Nicklas
Issue Date: 3-Apr-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Anesthesiology & Intensive Care Medicine
Parts of work: I. Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a prospective co-hort study on patient-perceived quality of recovery Oscarsson N, Arnell P, Lodding P, Ricksten S-E, Seeman-Lodding H, Int J Radiation Oncol Biol Phys, 87 (4), 670–675, 2013

II.Hyperbaric oxygen treatment reverses radiation-induced profibrotic and oxidative stress responses in a rat model Oscarsson N, Ny L, Mölne J, Lind F, Ricksten S-E, Seeman-Lodding H, Giglio D Free Radical Biology and Medicine, 103, 248–255, 2017

III. Hyperbaric oxygen reverses radiation-induced cell death in human urothelial and endothelial cells – development of a cell model Oscarsson N, Podmolikova L, Seeman-Lodding H, Bergo M, Giglio D (Manuscript).

IV. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial Oscarsson N, Müller B, Rosén A, Lodding Pär, Mölne J, Giglio D, Hjelle KM, Vaagbø G, Hyldegaard O, Vangedal M, Salling L, Kjellberg A, Lind F, Ettala O, Arola O, Seeman-Lodding H Lancet Onc Epub 2019 Sep 16

Date of Defence: 2020-05-15
Disputation: Fredagen den 15 maj 2020, kl. 16.00, föreläsningssal Karl Kylberg, sal 2320, Medicinaregatan 7B, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Hyperbaric oxygen treatment
hyperbaric oxygen
late radiation-induced injury
reactive oxygen species
radiation therapy
quality of life
Abstract: Introduction Cancer is affecting a growing number of persons. Still, the treatment and survival of cancer is improving. Radiation therapy is used in the treatment of cancer. Late radiation-induced injuries afflict 5–15% of irradiated patients. The urinary bladder and bowel may be affected after irradiation of cancer in the pelvic region. Symptoms can be severe, with impaired health related quality of life (HRQoL). Hyperbaric oxygen therapy (HBOT) involves breathing oxygen at high ambient pr... more
ISBN: 978-91-7833-801-6 (PDF)
978-91-7833-800-9 (PRINT)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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