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Novel biomarkers associated with histotype and clinical outcome in early-stage ovarian carcinoma


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Title: Novel biomarkers associated with histotype and clinical outcome in early-stage ovarian carcinoma
Authors: Engqvist, Hanna
E-mail: hanna.engqvist@gu.se
Issue Date: 15-Apr-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Oncology
Parts of work: I. Engqvist H, Parris TZ, Werner Rönnerman E, Söderberg E, Biermann J, Mateoiu C, Sundfeldt K, Kovács A, Karlsson P, Helou K. (2018). Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall survival. Oncotarget, 12;9(80), 35162-35180.
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II. Engqvist H, Parris TZ, Kovács A, Nemes S, Werner Rönnerman E, De Lara S, Biermann J, Sundfeldt K, Karlsson P, Helou K. (2019). Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas. BMC Cancer, 18;19(1), 928.
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III. Engqvist H, Parris TZ, Kovács A, Werner Rönnerman E, Sundfeldt K, Karlsson P, Helou K. Validation of novel prognostic biomarkers for early-stage clear-cell, endometrioid and mucinous ovarian carcinomas using immunohistochemistry. (2020). Frontiers in Oncology, section Women's Cancer, 18;10, 162.
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IV. Engqvist H, Parris TZ, Biermann J, Werner Rönnerman E, Larsson P, Sundfeldt K, Kovács A, Karlsson P, Helou K. Integrative genomics approach identifies molecular features associated with early-stage ovarian carcinoma histotypes. Submitted (2020).
Date of Defence: 2020-05-07
Disputation: Torsdagen den 7 maj 2020, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: ovarian carcinoma
histotype-specific diagnosis and prognosis
molecular biomarker
outcome prediction
integrative analysis
Abstract: Ovarian cancer is a collective name for multiple malignancies deriving from or involving the ovary, mainly comprising five histotypes of epithelial origin (clear-cell (CCC), endometrioid (EC), high-grade serous (HGSC), low-grade serous (LGSC), and mucinous carcinomas (MC)) with varying clinical (e.g. risk factors, survival outcome, response to therapy) and molecular behavior (e.g. origin, genetic characteristics). Despite known differences in disease states, the majority of ovarian carcinomas ar... more
ISBN: 978-91-7833-896-2 (PRINT)
978-91-7833-897-9 (PDF)
URI: http://hdl.handle.net/2077/63246
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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