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Transplantation of normal and decellularized syngeneic, allogeneic and xenogeneic cardiac tissue in mice and non-human primates


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Title: Transplantation of normal and decellularized syngeneic, allogeneic and xenogeneic cardiac tissue in mice and non-human primates
Authors: Methe, Ketaki
E-mail: ketaki.methe@transplant.gu.se
Issue Date: 5-Mar-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Surgery
Parts of work: I. Methe K., Bäckdahl H., Johansson B.R., Nayakawde N., Dellgren G., Sumitran-Holgersson S.; An Alternative Approach to Decellularize Whole Porcine Heart, BioResearch Open Access. 2014 December; 3(327-3361;3(6):327-38.
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II. Methe K., Wagner K.R., Nayakawde N.B., Banerjee D., Patil P., Antony D., Travnikova G., Premaratne G.U., Olausson M.; Immune response to normal and decellularised scaffolds in mouse, pig and non-human primates (Submitted)

III. Methe K., Ghosh S., Sihlbom C., Nayakawde N., Wagner K.R., Patil P., Premaratne G.U., Olausson M.; Comparative proteomics of decellularized cardiac scaffolds from mouse, pig and non-human primates (Submitted)

IV. Methe K., Nayakawde N., Banerjee D., Travnikova G., Olausson M.; Cross-talk Between Different Immune Regulatory Pathways Determines the Fate of Decellularized Grafts After Implantation (Submitted)
Date of Defence: 2020-03-27
Disputation: Fredagen den 27 mars 2020, kl 9.00, Hörsal Karl Isaksson, Medicinaregatan 16A, Göteborg
https://sahlgrenska.gu.se/forskning/aktuellt/evenemang/?eventId=70137049136
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Decellularization
Cardiac tissue
Syngeneic
Allogeneic
Xenogeneic
Non-human primate
Abstract: Introduction Because of the restricted inherent capacity of regeneration and healing, transplantation is the only treatment for end-stage heart failure but it has limitations of donor shortage and graft rejection. Cardiac tissue engineering strategies might help to alleviate this problem. Organ specific, biocompatible and biodegradable extracellular matrices (ECM) could be the preferred option for a suitable scaffolding material. However, clinical trials with these matrices is still not routine... more
ISBN: 978-91-7833-855-9 (PDF)
978-91-7833-854-2 (Print)
URI: http://hdl.handle.net/2077/63243
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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