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Functional studies of purinergic and cholinergic interactions in the rat urinary bladder - Characterization of ATP-evoked urothelial release of acetylcholine


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Title: Functional studies of purinergic and cholinergic interactions in the rat urinary bladder - Characterization of ATP-evoked urothelial release of acetylcholine
Authors: Johanna, Stenqvist
E-mail: johanna.stenqvist@pharm.gu.se
Issue Date: 26-Mar-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: I. Stenqvist J, Winder M, Carlsson T, Aronsson P & Tobin G. Urothelial acetylcholine involvement in ATP-induced contractile responses of the rat urinary bladder. Eur J Pharmacol. 2017, 809:253-260.
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II. Stenqvist J, Carlsson T, Winder M & Aronsson P. Effects of caveolae depletion and urothelial denudation on purinergic and cholinergic signaling in healthy and cyclophosphamide-induced cystitis in the rat bladder. Auton Neurosci. 2018, 213:60-70.
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III. Stenqvist J, Carlsson T, Winder M & Aronsson P. Functional atropine sensitive purinergic responses in the healthy rat bladder. Submitted

IV. Stenqvist J, Aronsson P, Carlsson T, Winder M & Tobin G. In vivo paracrine effects of ATP-induced urothelial release of acetylcholine in the rat urinary bladder. Submitted
Date of Defence: 2020-04-17
Disputation: Fredagen den 17 april 2020, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg https://gu-se.zoom.us/j/4687916160
Degree: Doctor of Philosophy (Pharmaceutical science)
Publication type: Doctoral thesis
Keywords: ATP
acetylcholine
urothelium
caveolae
afferents
cystitis
Abstract: Functional interplays between different transmitter systems are known to affect the signalling of the micturition reflex arc. The functional implications of many of these interactions, such as between ATP and acetylcholine, have yet to be unravelled. This thesis aimed to identify and characterize the functional importance of a proposed atropine-sensitive component in purinergic responses. Furthermore, its impact on afferent signalling and changes during experimental (cyclophosphamide-induced) cy... more
ISBN: 978‐91‐7833‐856‐6 (Print)
978‐91‐7833‐857‐3 (PDF)
URI: http://hdl.handle.net/2077/63235
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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