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Immunological effects of isolated regional perfusion in malignant melanoma


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Title: Immunological effects of isolated regional perfusion in malignant melanoma
Authors: Johansson, Junko
E-mail: junko.johansson@gu.se
Issue Date: 8-May-2019
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Surgery
Parts of work: I. Johansson, J., Kiffin, R., Andersson, A., Lindnér, P., Naredi, P., Olofsson Bagge, R. and Martner, A. Isolated Limb Perfusion With Melphalan Triggers Immune Activation in Melanoma Patients. Frontiers in Oncology, 2018, 8(570)
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II. Martner, A., Johansson, J., Ben-Shabat, I. and Olofsson Bagge, R. Melphalan, Antimelanoma Immunity, and Inflammation—Letter. Cancer Research, 2015, 75(24)
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III. Johansson, J., Kiffin, R., Aydin, E., Nilsson, M.S., Hellstrand, K., Lindnér, P., Naredi, P., Olofsson Bagge, R. and Martner, A. Isolated limb perfusion with melphalan activates interferon-stimulated genes to induce tumor regression in patients with metastatic melanoma. Submitted

IV. Johansson, J., Kiffin, R., Siarov, J., Mölne, J., Naredi, P., Olofsson Bagge, R., Martner, A. and Lindnér, P. Presence of activated T cells in peripheral blood correlates to longer progression-free survival in patients undergoing isolated hepatic perfusion for uveal melanoma liver metastasis. Manuscript
Date of Defence: 2019-05-29
Disputation: Onsdagen den 29 maj 2019, kl. 09.00, Hörsal Ivan Ivarsson, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Melanoma
Isolated regional perfusion
ILP
IHP
Melphalan
Immunogenic cell death
T cells
Monocytes
ISG
Abstract: Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. Isolated limb perfusion (ILP) is approved for treatment of cutaneous metastatic melanoma, while the efficacy of isolated hepatic perfusion (IHP) is under evaluation for the t... more
ISBN: 978-91-7833-422-3 (print)
978-91-7833-423-0 (electronic)
URI: http://hdl.handle.net/2077/59070
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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