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Regenerative effects of mesenchymal stem cell-derived exosomes

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Title: Regenerative effects of mesenchymal stem cell-derived exosomes
Authors: Wang, Xiaoqin
Issue Date: 6-Feb-2019
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Biomaterials
Parts of work: I. Wang X, Omar O, Vazirisani F, Thomsen P, Ekström K. Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation. PLoS One. 2018; 13(2): e0193059.

II. Wang X, Philip J, Vazirisani F, Tsirigoti C, Thomsen P, Ekström K. The impact of in vitro aging on the release of extracellular vesicles from human mesenchymal stem cells. In manuscript.

III. Wang X, Shah FA, Vazirisani F, Johansson A, Palmquist A, Omar O, Ekström K, Thomsen P. Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces. Submitted for publication.
Date of Defence: 2019-03-01
Disputation: Fredagen den 1 mars 2019, kl. 13.00, Föreläsningssalen våning 5, avdelningen för biomaterialvetenskap, Arvid Wallgrens backe 20, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: aging
cell adhesion
cell-material interaction
extracellular vesicles
mesenchymal stem cells
osteogenic differentiation
Abstract: Mesenchymal stem cells (MSCs) play pivotal roles for bone regeneration by virtue of their osteogenic differentiation ability and immunomodulatory capacity. Recently, secretion of exosomes/extracellular vesicles (EVs) has been suggested as a new mechanism of MSC-based therapy. MSC-derived EVs/exosomes have shown promising effects in tissue regeneration and immunomodulation, which are attributed to their regulatory effects in various processes. The overall objective of this thesis was to explore t... more
ISBN: 978-91-7833-340-0 (PRINT)
978-91-7833-341-7 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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