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On the Effects of Serotonin Reuptake Inhibitors in Major Depression


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/58234

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Title: On the Effects of Serotonin Reuptake Inhibitors in Major Depression
Authors: Hieronymus, Fredrik
E-mail: fredrik.hieronymus@neuro.gu.se
Issue Date: 25-Jan-2019
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: Fredrik Hieronymus, Johan F. Emilsson, Staffan Nilsson, Elias Eriksson. Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression. Mol. Psychiatry 2016;21:523-530.
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Fredrik Hieronymus, Staffan Nilsson, Elias Eriksson. A mega-analysis of fixed-dose trials reveals dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake inhibitors. Transl. Psychiatry. 2016;6:e834.
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Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson. Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression. Mol. Psychiatry. 2018;23:1731-1736.
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Jakob Näslund, Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson. Effects of selective serotonin reuptake inhibitors on rating-scale-assessed suicidality in adults with depression. Br. J. Psychiatry 2018;212:148-154.
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Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson. Impact of baseline severity on the effects of selective serotonin reuptake inhibitors in depression: an item-based patient-level post hoc analysis. Submitted.

Alexander Lisinski, Fredrik Hieronymus, Jakob Näslund, Staffan Nilsson, Elias Eriksson. Item-based analysis of the effects of duloxetine in depression: a patient-level post hoc study. Submitted.
Date of Defence: 2019-02-15
Disputation: Fredagen den 15 februari 2019, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: antidepressants
antidepressive agents
depression
major depressive disorder
selective serotonin reuptake inhibitor
SNRI
SSRI
Abstract: This thesis focuses on the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and how these are reflected by the Hamilton Depression Rating Scale (HDRS). To this end, we have assembled a large data set of placebo-controlled SSRI trials in major depression, and used this for a series of post-hoc patient-level analyses. Thus, in a population of 8 262 patients treated with either of four SSRIs (citalopram, fluoxetine, paroxetine, or sertraline) or placebo, we have assessed (1... more
ISBN: 978-91-7833-312-7 (PRINT)
978-91-7833-313-4 (PDF)
URI: http://hdl.handle.net/2077/58234
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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