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Glucagon-like peptide-1 and alcohol-mediated behaviors in rodents


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/57960

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Title: Glucagon-like peptide-1 and alcohol-mediated behaviors in rodents
Authors: Vallöf, Daniel
E-mail: daniel.vallof@gu.se
Issue Date: 18-Jan-2019
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: I. Vallöf D, Maccioni P, Colombo G, Mandrapa M, Jörnulf JW, Egecioglu E, Engel JA, Jerlhag E. The glucagon-like peptide-1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents. Addict Biol. 2016, 21(2):422-37
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II. Vallöf D, Kalafateli AL, Jerlhag E. Brain region specific glucagon-like peptide-1 receptors regulate alcohol-induced behaviors in rodents. Submitted

III. Vallöf D, Jerlhag E. Glucagon-like peptide-1 receptors within the nucleus of the solitary tract regulate alcohol-mediated behaviors in rodents. Submitted

IV. Vallöf D, Kalafateli AL, Jerlhag E. Alcohol intake in male and female rats following long-term treatment with a glucagon-like peptide-1 receptor agonist. Manuscript
Date of Defence: 2019-02-08
Disputation: Fredagen den 8 februari 2019, kl. 9.00, Hörsal Karl Isaksson, Medicinaregatan 16, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Addiction
Dopamine
Gut-brain axis
Reward
Abstract: Alcohol use disorder (AUD) is a serious cause of morbidity and mortality. However, due to the limited efficacy of existing pharmacotherapies, further investigations of potential neurochemical targets are required to define new pharmacological interventions. In recent years, a pivotal role of the appetite regulatory peptide glucagon-like peptide-1 (GLP-1) in drug reinforcement and addiction processes has been identified. However, the ability of GLP-1 receptors (GLP-1R) to influence various alcoho... more
ISBN: 978-91-7833-289-2 (PDF)
978-91-7833-288-5 (PRINT)
URI: http://hdl.handle.net/2077/57960
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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