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Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies


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Title: Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies
Authors: Elf, Anna-Karin
E-mail: anna-karin.elf@vgregion.se
Issue Date: 6-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Surgery
Parts of work: I. Treatment with 177Lu-DOTATATE for metastasized NET – long-term effects and a tumour dosimetry model. Elf AK, Marin I, Rossi Norrlund R, Svensson J, Wängberg B, Nilsson O, Bernhardt P, Johanson V. In manuscript

II. Can SSTR2 expression in previously resected SI-NETs predict overall survival after PRRT treatment of remaining lesions? Elf AK, Johanson V, Marin I, Bergström A, Nilsson O, Svensson J, Wängberg B, Bernhardt P, Elias E. In manuscript

III. NAMPT Inhibitor GMX1778 Enhances the Efficacy of 177Lu-DOTATATE Treatment of Neuroendocrine Tumours. Elf AK, Bernhardt P, Hofving T, Arvidsson Y, Forsell-Aronsson E, Wängberg B, Nilsson O, Johanson V. Journal of Nuclear Medicine 2017; 58(2):288-292
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IV. Radioembolization Versus Bland Embolization for Hepatic Metastases from Small Intestinal Neuroendocrine Tumors: Short-term Results of a Randomized Clinical Trial. Elf, AK, Andersson M, Henriksson O, Jalnefjord O, Ljungberg M, Svensson J, Wängberg B, Johanson V. World Journal of Surgery 2018; 42:506-513
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Date of Defence: 2018-11-23
Disputation: Fredagen den 23 november 2018, kl 13.00, Hjärtats aula, Blå Stråket 5, Sahlgrenska Universitetssjukhuset, Göteborg.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: neuroendocrine tumour
peptide receptor radionuclide therapy
somatostatin receptor 2 expression
radiosensitization
radioembolization
diffusion weighted imaging
Abstract: ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. Tumour response is variable and renal and haematological toxicity are dose-limiting side effects. In metastatic small intestinal NET (SI-NET) hepatic metastase... more
ISBN: 978-91-7833-188-8 (PDF)
978-91-7833-187-1 (PRINT)
URI: http://hdl.handle.net/2077/57953
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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