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Molecular Control of Organogenesis, Cell Fate Specification and Cell Differentiation: Genetic and Experimental Studies in the Mouse


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Title: Molecular Control of Organogenesis, Cell Fate Specification and Cell Differentiation: Genetic and Experimental Studies in the Mouse
Authors: Abdelghaffar Abdelgawwad El Shahawy, Maha
E-mail: maha.el.shahawy@odontologi.gu.se
Issue Date: 13-Dec-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Odontology. Department of Oral Biochemistry
Parts of work: Reibring CG, El Shahawy M, Hallberg K, Kannius-Janson M, Nilsson J, Parkkila S, Sly WS, Waheed A, Linde A, Gritli-Linde A. Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PloS One. 2014 May 1;9(5):e96007.
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El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 July 17; 13(7):e1006914.
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El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Sonic hedgehog signaling is required for Cyp26 expression during embryonic development. Manuscript.
Date of Defence: 2019-01-18
Disputation: Fredagen den 18 januari 2019, kl. 13.00, Föreläsningssal 3, Institutionen för odontologi, Medicinaregatan 12E, Göteborg
Degree: Doctor of Philosophy (Odontology)
Publication type: Doctoral thesis
Keywords: Carbonic anhydrase
CRE/LoxP
Glands
Merkel cells
Metaplasia
Patterning
Retinoic acid
Sonic Hedgehog
Tongue
Tooth
Abstract: Deciphering the mechanisms controlling normal development sheds light onto the etiopathogenesis of congenital malformations and diseases, and knowledge of the expression patterns of proteins and/or their encoding genes is necessary to understand developmental pocesses. Good models to study developmental processes, such as morphogenesis, tissue patterning, cell fate specification and cell differentiation include developing teeth and tongue. Carbonic anhydrases (CAs) are involved in several phys... more
ISBN: 978-91-7833-204-5 (PDF)
978-91-7833-203-8 (PRINT)
URI: http://hdl.handle.net/2077/57824
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för odontologi

 

 

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