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Brain-Gut Interactions in Irritable Bowel Syndrome (IBS)


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Title: Brain-Gut Interactions in Irritable Bowel Syndrome (IBS)
Authors: Grinsvall, Cecilia
E-mail: cecilia.grinsvall@gu.se
Issue Date: 4-Dec-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Inst of Medicine. Department of Internal Medicine and Clinical Nutrition
Parts of work: I: C. Grinsvall, H. Törnblom, J. Tack, L. Van Oudenhove#, M. Simrén#; Psychological factors selectively upregulate rectal pain perception in hypersensitive patients with irritable bowel syndrome; Neurogastroenterol Motil; 2015 Dec;27(12):1772-82.
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II: C. Grinsvall, H. Törnblom, J. Tack, L. Van Oudenhove#, M. Simrén#; Relationships between psychological state, abuse, somatization and visceral pain sensitivity in irritable bowel syndrome; United European Gastroenterol J; 2018 Mar;6(2):300-309.
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III: C. Grinsvall*, H. J. Ryu*, L. Van Oudenhove, P. Dupont, J.S. Labus, A. Gupta, M. Ljungberg, H. Törnblom, E. A. Mayer#, M. Simren#; Sensorimotor network gray matter morphometry in irritable bowel syndrome versus healthy controls: sex differences and associations with pain responses; In manuscript.

IV: C. Grinsvall, L. Van Oudenhove, P. Dupont, M. Ljungberg, H.J. Ryu, J.S. Labus, H. Törnblom, E.A. Mayer#, M. Simrén#; A somatization brain network in Irritable Bowel Syndrome (IBS) involves altered connectivity in brain regions with cognitive functions; In manuscript.
Date of Defence: 2019-01-18
Disputation: Fredagen den 18 januari 2019, kl. 9.00, Hjärtats aula, Vita stråket 12, Sahlgrenska Universitetssjukhuset/Sahlgrenska, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: visceral sensitivity
anxiety
depression
somatization
central sensitization
gray matter morphometry
Abstract: Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction defined by recurrent and longstanding abdominal pain and disturbed bowel habits. This thesis aims to deepen the knowledge about aberrant visceral sensory processing seen in a large group of patients with IBS, with particular focus on central mechanisms. The methods used were rectal balloon distensions using a barostat to evaluate rectal sensitivity, structural magnetic resonance imaging of the brain to investigate regio... more
ISBN: 978-91-7833-208-3 (PDF)
978-91-7833-207-6 (PRINT)
URI: http://hdl.handle.net/2077/57740
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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