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The Role of Estrogen Receptor α Signaling in the Regulation of Bone Mass


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/57672

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Title: The Role of Estrogen Receptor α Signaling in the Regulation of Bone Mass
Authors: Farman, Helen
E-mail: helen.farman@gu.se
Issue Date: 6-Dec-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Clinical Nutrition
Parts of work: I. Farman HH, Windahl SH, Westberg L, Isaksson H, Egecioglu E, Schele E, Ryberg H, Jansson JO, Tuukkanen J, Koskela A, Xie SK, Hahner L, Zehr J, Clegg DJ, Lagerquist MK, and Ohlsson C. Female mice lacking estrogen receptor - α in hypothalamic proopiomelanocortin (POMC) neurons display enhanced estrogenic response on cortical bone mass. Endocrinology, 2016. 157(8):3242-52.
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II. Börjesson AE, Farman HH, Engdahl C, Koskela A, Sjögren K, Kindblom JM, Stubelius A, Islander U, Carlsten H, Antal MC, Krust A, Chambon P, Tuukkanen J, Lagerquist MK, Windahl SH, and Ohlsson C. The role of activation functions 1 and 2 of estrogen receptor-α for the effects of estradiol and selective estrogen receptor modulators (SERMs) in male mice. Journal of Bone and Mineral Research, 2013. 28(5):1117-26.
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III. Farman HH, Wu J, Gustafsson KL, Windahl SH, Kim SH, Katzenellenbogen JA, Ohlsson C, and Lagerquist MK. Extra-nuclear effects of estrogen on cortical bone in males require ERαAF-1. Journal of Molecular Endocrinology, 2017. 58(2):105-111.
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IV. Farman HH, Gustafsson KL, Henning P, Grahnemo L, Lionikaite V, Movérare-Skrtic S, Wu J, Ryberg H, Koskela A, Tuukkanen J, Levin ER, Ohlsson C, and Lagerquist MK. Membrane estrogen receptor-α is essential for estrogen signaling in the male skeleton. Journal of Endocrinology, 2018. 239(3):303-312.
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Date of Defence: 2019-01-11
Disputation: Fredagen den 11 januari 2019, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: estrogen receptor α
bone
estrogen
Abstract: Estrogens are major regulators of skeletal growth and maintenance in both females and males. Estrogen receptor α (ERα) is the main mediator of estrogenic effects in bone. Thus, estrogen signaling via ERα is a target for treatment of estrogen-related bone diseases including osteoporosis. However, treatment with estrogen leads to side effects in both genders. The aim of this thesis was to characterize different ERα signaling pathways in order to increase the knowledge regarding the mechanisms behi... more
ISBN: 978-91-7833-252-6 (PDF)
978-91-7833-251-9 (PRINT)
URI: http://hdl.handle.net/2077/57672
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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