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Vitamin A and Bone: Studies in vivo and in vitro


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/57426

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Title: Vitamin A and Bone: Studies in vivo and in vitro
Authors: Lionikaite, Vikte
E-mail: vikte.lionikaite@gu.se
Issue Date: 28-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Inst of Medicine. Department of Internal Medicine and Clinical Nutrition
Parts of work: I. Lionikaite V, Gustafsson KL, Westerlund A, Windahl SH, Koskela A, Tuukkanen J, Johansson H, Ohlsson C, Conaway HH, Henning P, and Lerner UH. Clinically relevant doses of vitamin A decrease cortical bone mass in mice. Journal of Endocrinology, 2018; 239(3): 389-402.
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II. Lionikaite V, Henning P, Drevinge C, Shah FA, Palmquist A, Wikström P, Windahl SH, and Lerner UH. Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation. Submitted.

III. Lionikaite V, Westerlund A, Conaway HH, Henning P, and Lerner UH. Effects of retinoids on physiologic and inflammatory osteoclastogenesis in vitro. Journal of Leukocyte Biology, 2018; 1-13. Epub ahead of print.
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IV. Henning P, Lionikaite V, Westerlund A, Conaway HH, and Lerner UH. Retinoids enhance osteoclastogenesis in periosteal bone cell cultures. Manuscript.
Date of Defence: 2018-12-18
Disputation: Tisdagen den 18 december 2018, kl 9.00, Hjärtats aula, Vita stråket 12, Sahlgrenska Universitetssjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: vitamin A
retinol
osteoclasts
osteoblasts
cortical bone
osteoporosis
Abstract: Background: Excess vitamin A is associated with decreased cortical bone and increased risk of fractures in humans. The aim of the present thesis was to assess the importance of vitamin A on the skeleton and bone cells in in vivo animal studies and mechanistic in vitro experiments. In vivo, we used clinically relevant doses of vitamin A to investigate its effects on bone after prolonged administration and on the anabolic bone response to mechanical loading. In vitro, we aimed to determine how ret... more
ISBN: 978-91-7833-123-9 (PRINT)
978-91-7833-124-6 (PDF)
URI: http://hdl.handle.net/2077/57426
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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